{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:00:24Z","timestamp":1793736024135,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Portal vein obstruction (PVO) is a known complication after pediatric liver transplantation (pLT). Effective management strategies are crucial in improving patient outcomes. This study investigated the various practice patterns related to PVO management to clarify the degree of consensus on the diverse facets of care involved in addressing PVO after pLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A self\u2010reported evaluation was conducted using a scanned, paper\u2010based survey among specialized pLT centers participating in the Portal vein Obstruction Revascularization Therapy After Liver transplantation (PORTAL) registry. The survey consisted of 30 questions covering the current practices regarding PVO, including experience, team composition, follow\u2010up and screening protocol, assessment criteria, postprocedural care, and radiologic follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The survey was returned by 25 centers (100%) from different regions worldwide. All centers used Doppler ultrasound (DUS) for PVO screening in the outpatient department. Noninvasive diagnostic criteria used during DUS assessment included anastomotic velocity (50%) and anastomotic\u2010to\u2010pre\u2010anastomotic velocity ratio (54%). Digital subtraction angiography was used by 79% of respondents to diagnose portal vein anastomosis stenosis, which led to diagnostic cutoff values including a narrowing of the visual aspect of the anastomosis of \u2265\u200950% (80%) and a pressure gradient \u2265\u20095\u2009mmHg (50%). PTA was identified as a standard treatment for PVO. A remarkable heterogeneity was observed in postinterventional anticoagulation and surveillance protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The care for PVO after pLT lacks standardization, resulting in substantial variation across healthcare centers. There is a need to establish a clear consensus on PVO management after pLT to guarantee optimal care.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NL9261.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70625","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:59:57Z","timestamp":1748307597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Portal Vein Obstruction in Pediatric Liver Transplant Patients: An Evaluation of Self\u2010Reported Management Practices"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7235-4315","authenticated-orcid":false,"given":"Lydia","family":"Sieben","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Medical Center Groningen, Division of Pediatric Gastroenterology and Hepatology University of Groningen Groningen The Netherlands"},{"name":"Department of Radiology Medical Imaging Center University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7676-1944","authenticated-orcid":false,"given":"Bader A.","family":"Alfares","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical Imaging Center University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"King Faisal Specialist Hospital and Research Center Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben H.","family":"de Kleine","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Center Groningen, Division of Hepatobiliary Surgery &amp; Liver Transplantation University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Wildhaber","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Division of Child and Adolescent Surgery, Geneva University Hospitals University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Casswall","sequence":"additional","affiliation":[{"name":"Department Clinical Interventions and Technology CLINTEC Division for Paediatrics, Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department Clinical Interventions and Technology CLINTEC Division for Transplantation Surgery, Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Delle","sequence":"additional","affiliation":[{"name":"Department Clinical Science, Intervention and Technology CLINTEC Division for Interventional Radiology, Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Aldrian","sequence":"additional","affiliation":[{"name":"Department of Paediatrics I Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Berchtold","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant and Thoracic Surgery Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg F.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics I Medical University of Innsbruck Innsbruck Austria"},{"name":"Institute of Cell Biology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kalici\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Organ Transplantation The Children's Memorial Health Institute Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Markiewicz\u2010Kijewska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Organ Transplantation The Children's Memorial Health Institute Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kolesnik","sequence":"additional","affiliation":[{"name":"Cardiovascular Interventions Laboratory, The Children's Memorial Health Institute Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Quintero","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Liver transplant Vall d'Hebron 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Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pinelli","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation ASST Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mureo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center, National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seisuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center, National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Uchida","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center, National Center for Child Health and Development Tokyo 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