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Clinical manifestations vary widely, from mild constitutional symptoms to severe organ dysfunction. This review aims to thoroughly explore drug\u2010induced renal vasculitis, focusing on its etiology, pathological mechanisms, clinical manifestations, diagnostic challenges, and therapeutic approaches. This review aims to summarize current knowledge and highlight areas requiring further research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted using PubMed, MEDLINE, Embase, and Cochrane Library databases. We included peer\u2010reviewed journal articles and excluded those with insufficient data, poor quality, or lack of relevance. The search terms included combinations of \u201crenal vasculitis,\u201d \u201cdrug\u2010induced vasculitis,\u201d \u201cdrug\u2010related nephritis,\u201d \u201cmedication\u2010induced renal vasculitis,\u201d and specific drug names. An initial search yielded 13,192 articles, of which 13,103 were excluded due to irrelevance, duplication, or outdated information. After full\u2010text review, 99 peer\u2010reviewed articles were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Discontinuation of the offending drug is the primary and most crucial step in managing drug\u2010induced renal vasculitis. Prognosis is generally more favorable than primary vasculitis, with a high remission rate if the offending drug is stopped early. Due to its rarity, epidemiological data is limited. Diagnosis frequently relies on autoantibodies [antineutrophil cytoplasm antibodies (ANCA), myeloperoxidase (MPO), antinuclear antibody (ANA)] and clinical symptoms, with renal biopsy confirming it. Factors such as high\u2010dose and long\u2010term drug use, as well as genetic predispositions, increase the risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review provides a comprehensive overview of drug\u2010induced renal vasculitis, discussing what is known and identifying gaps in understanding. While discontinuing the causative drug remains the cornerstone of management, further research is needed, particularly in developing a formal tool to assess the quality of studies and minimize selection bias.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70667","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:49:46Z","timestamp":1744811386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drug\u2010Induced Renal Vasculitis: Etiology, Pathogenesis, Clinical Manifestations, and Therapeutic Approaches\u2014A Narrative Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3847-2027","authenticated-orcid":false,"given":"Hashim","family":"Mohamed Siraj","sequence":"first","affiliation":[{"name":"Faculty of Medicine Ivane Javakhishvili Tbilisi State University Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8599-6861","authenticated-orcid":false,"given":"Masab","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5142-5025","authenticated-orcid":false,"given":"Sampda Sanjaykumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"GMERS Medical College Gandhinagar Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1694-2592","authenticated-orcid":false,"given":"Afreen","family":"Begum","sequence":"additional","affiliation":[{"name":"Department of Medicine ESIC Medical College and Hospital Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5248-0749","authenticated-orcid":false,"given":"Muhammad Husnain","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Medicine Tentishev Satkynbai Memorial Asian Medical Institute Kant Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6747-7980","authenticated-orcid":false,"given":"Muhammad","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4802-7102","authenticated-orcid":false,"given":"Roba Kamaleldin Moustafa Kamel","family":"Aref Elsayed","sequence":"additional","affiliation":[{"name":"Gulf Medical University Ajman United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6579-9380","authenticated-orcid":false,"given":"Muhammad Hamza","family":"Tahir","sequence":"additional","affiliation":[{"name":"Govt Sadiq Abbasi Hospital Bahawalpur Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"issue":"1","key":"e_1_2_21_2_1","first-page":"12","article-title":"Drug\u2010Induced Vasculitis: A Clinical and Pathological Review","volume":"70","author":"Radi\u0107 M.","year":"2012","journal-title":"Netherlands Journal of Medicine"},{"key":"e_1_2_21_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.055"},{"key":"e_1_2_21_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2006.03.003"},{"key":"e_1_2_21_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.058271"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1991.tb00342.x"},{"key":"e_1_2_21_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb00496.x"},{"key":"e_1_2_21_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh832"},{"key":"e_1_2_21_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.10.043"},{"key":"e_1_2_21_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.2.556"},{"key":"e_1_2_21_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740701607117"},{"key":"e_1_2_21_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.05.026"},{"issue":"1","key":"e_1_2_21_13_1","first-page":"86","article-title":"Autoantibodies to Myeloperoxidase in Systemic Sclerosis","volume":"24","author":"Locke I. 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