{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:29:53Z","timestamp":1790126993605,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Atopic dermatitis (AD) is a common chronic inflammatory skin condition, affecting 15%\u201320% of children and up to 10% of adults. It has a significant impact on patients' quality of life and represents a considerable burden on healthcare systems. Management strategies aim to restore the skin barrier, reduce inflammation, and achieve physiological and homeostatic balance. This study evaluates the safety and efficacy of a new dermocosmetic formulation combining poly\u2010<jats:sc>l<\/jats:sc>\u2010lysine biovectors with vitamins A and C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010arm, open\u2010label study was conducted on 20 patients diagnosed with AD, including 14 women and 6 men aged between 24 and 63, with skin phototypes of Fitzpatrick I\u2013VI. Treatment involved sequential application of poly\u2010<jats:sc>l<\/jats:sc>\u2010lysine G2\/vitamin C in the morning and poly\u2010<jats:sc>l<\/jats:sc>\u2010lysine G3\/vitamin A in the evening for 28 days, on the face, hands, and body. Outcomes were assessed using the Dermatology Life Quality Index (DLQI) and SCORAD scores. Additional assessments included a visual analog scale for pruritus and sleep disturbance, as well as patient self\u2010report questionnaires on skin improvement and treatment satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment was well\u2010tolerated, with no adverse effects and no relapses of AD. After 28 days, patients showed a significant reduction in DLQI (\u221261.8%, Cohen's <jats:italic>d<\/jats:italic>\u2009=\u20091.20) and SCORAD (\u221241.8%, Cohen's <jats:italic>d<\/jats:italic>\u2009=\u20091.05) scores. Objective improvements included reductions in erythema (\u221250%), dryness (\u221260%), and pruritus (\u221250%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates the potential of poly\u2010<jats:sc>l<\/jats:sc>\u2010lysine\u2010based dermocosmetics combined with vitamins A and C to improve the symptoms and quality of life of patients suffering from AD. The formulations were well\u2010tolerated and effective in restoring the skin barrier and reducing inflammation. Further large\u2010scale controlled studies are needed to validate these results and explore long\u2010term efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70676","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T11:00:26Z","timestamp":1744801226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Prospective Open\u2010Label Study of Tolerance and Effectiveness of Sequential Dermocosmetic Treatments Combining Poly\u2010<scp>l<\/scp>\u2010Lysine Biovectors With Vitamins A and C"],"prefix":"10.1002","volume":"8","author":[{"given":"Bertrand","family":"Nassar","sequence":"first","affiliation":[{"name":"Research and Expertise Group, French Association for Medical Research Advancement (AFPREMED) Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9488-1577","authenticated-orcid":false,"given":"Hafid","family":"Belhadj\u2010Tahar","sequence":"additional","affiliation":[{"name":"Research Department Dermabel Cosmetics France Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Jin","sequence":"additional","affiliation":[{"name":"Research and Expertise Group, French Association for Medical Research Advancement (AFPREMED) Toulouse France"},{"name":"International Research Center for Biological Sciences Shanghai Ocean University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Research and Expertise Group, French Association for Medical Research Advancement (AFPREMED) Toulouse France"},{"name":"International Research Center for Biological Sciences Shanghai Ocean University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.032"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.043"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00277.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370226"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.01047.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06385.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.07.004"},{"key":"e_1_2_11_9_1","article-title":"Quality of Life of Women Living With Eczema: A Qualitative Study","author":"Afzal Z.","journal-title":"Journal of Research in Psychology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12193-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.033"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7015.1241"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042803"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta4370"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38376.439653.D3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07538.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198800365-00005"},{"key":"e_1_2_11_18_1","first-page":"127","article-title":"Adrenocortical Function During Prolonged Treatment With Clobetasone Butyrate in Children With Chronic Atopic Dermatitis and Elevated IgE Levels","volume":"5","author":"Boner A. 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