{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:58:02Z","timestamp":1787162282325,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Septic shock is a serious infection\u2010related condition that has a big effect on public health. To improve organ perfusion and prognosis in septic shock patients with chronic high blood pressure, optimal mean arterial pressure (MAP) targets are needed. This narrative review aims to summarize existing knowledge and factors to determine the most effective MAP targets in septic shock patients with chronic hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A careful review of relevant literature was conducted to understand the factors that affect MAP targets in septic shock patients with chronic hypertension. Long\u2010term hypertension patients require personalized MAP targets based on age, health conditions, and septic shock severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>five studies were identified in this narrative review. Guidelines suggest 65\u201075\u2009mmHg for most cases, but higher targets may be beneficial for proper organ perfusion. Continuous hemodynamic monitoring allows dynamic adjustment of MAP targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is crucial to implement personalized MAP management strategies to achieve optimal outcomes for patients with chronic hypertension who are experiencing septic shock. However, there is a lack of consensus on optimal MAP targets among patients with chronic hypertension, which may require higher MAP targets to maintain adequate tissue perfusion. An approach that considers each patient's unique characteristics and includes ongoing assessment is critical for achieving the best MAP targets and improving patient prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70696","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:07:39Z","timestamp":1747638459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimizing Mean Arterial Pressure Targets for Septic Shock Patients With Chronic Hypertension: A Narrative Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5435-3296","authenticated-orcid":false,"given":"Mutaz I.","family":"Othman","sequence":"first","affiliation":[{"name":"Nursing Department Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad M.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Nursing Department Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Abdelwahab","sequence":"additional","affiliation":[{"name":"Nursing Department Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Hssain","sequence":"additional","affiliation":[{"name":"Department of Critical Care Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-4119","authenticated-orcid":false,"given":"Abdulqadir J.","family":"Nashwan","sequence":"additional","affiliation":[{"name":"Nursing Department Hamad Medical Corporation Doha Qatar"},{"name":"Department of Public Health, College of Health Sciences QU Health Qatar University Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.628302"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00369.2020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14199"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-1120"},{"key":"e_1_2_10_6_1","first-page":"22","article-title":"Sepsis\u2010Induced Cardiac Dysfunction: Pathophysiology and","volume":"4","author":"Chen J.","year":"2016","journal-title":"experimental treatments: Queen Mary University of London"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04255-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.962670"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.11.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06595-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0958-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199712000-00005"},{"key":"e_1_2_10_13_1","unstructured":"S. D.Kuragayala S. R.Ganti S.Sirga andH. B.Kommula 2019. Ideal Mean Arterial Pressure Target in Septic Shock: The Hunt Goes On! Age 58 no. 18.2557.29\u201017."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0866-0"},{"issue":"7","key":"e_1_2_10_15_1","first-page":"777","article-title":"Mean Arterial Pressure Target in Patients With Septic Shock","volume":"82","author":"Beloncle F.","year":"2016","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312173"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2016.04.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14020176"},{"key":"e_1_2_10_19_1","volume-title":"Septic Shock and Vasopressor Therapy: The Impact of Excessive Mean Arterial Pressure Values","author":"Mims B. 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