{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:53:33Z","timestamp":1753869213409,"version":"3.41.2"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurological manifestations are increasingly recognized in COVID\u201019 patients, yet their prevalence and clinical significance remain understudied. This study aimed to determine the incidence and significance of neurological symptoms and their associations with demographic, clinical, and laboratory parameters in hospitalized COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A cross\u2010sectional study was conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran, from February 2020 to February 2021. A total of 540 RT\u2010PCR\u2010confirmed COVID\u201019 patients were included. Data on demographics, comorbidities, clinical symptoms, neurological manifestations (e.g., myalgia, headache, smell\/taste impairment, dizziness), and laboratory findings were collected. Statistical analyses were performed using SPSS version 20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Myalgia was the most common neurological symptom (33.9%), followed by headache (16.7%), smell\/taste impairment (10.2%), and dizziness (6.9%). A significantly higher prevalence of myalgia and smell\/taste impairment was observed in patients under 50 years old (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). Patients with myalgia also had a significantly higher prevalence of prior chronic heart disease and were more likely to experience concurrent smell\/taste impairment (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). Notably, while some inflammatory markers were elevated in both patients with and without myalgia and smell\/taste impairment, the increase was significantly less pronounced in those exhibiting these neurological symptoms (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). Additionally, patients with headache and smell\/taste impairment were less frequently admitted to the ICU (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). A statistically significant co\u2010occurrence was also observed among the presence of headache, dizziness, and smell\/taste impairment in COVID\u201019 patients (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neurological symptoms are prevalent in COVID\u201019 patients and may serve as markers of disease severity and progression. Recognizing these manifestations can aid in early diagnosis and inform tailored management strategies. Further research with larger, diverse populations and advanced diagnostic tools is needed to validate these findings and better understand the mechanisms underlying COVID\u201019\u2010related neurological involvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70723","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T13:07:16Z","timestamp":1744981636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significance of Neurological Manifestations and Their Association With Clinical Outcomes in Hospitalized COVID\u201019 Patients in Bandar Abbas, Iran: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Ahmadagha","family":"Negahi","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Hormozgan Health Institute Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parivash","family":"Davoodian","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Hormozgan Health Institute Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Hormozgan Health Institute Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Nabavi","sequence":"additional","affiliation":[{"name":"Student Research Committee University of Medical Sciences Bandar Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0408-5476","authenticated-orcid":false,"given":"Niloufar","family":"Khatibzade\u2010Nasari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Qeshm branch Islamic Azad University Qeshm Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mobina","family":"Imeri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Qeshm branch Islamic Azad University Qeshm Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108427"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-020-01079-7"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1036"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116969"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51210"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18073673"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02161-4"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01367-8"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.05.024"},{"key":"e_1_2_17_11_1","first-page":"3773","article-title":"Neurological Manifestations of SARS\u2010CoV\u20102 Infection Among Hospitalized Patients","volume":"36","author":"Aydin A. 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