{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:53:34Z","timestamp":1753869214404,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the effect of plasma exchange (PE) on the prognosis of patients with hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The basic information (gender, age, blood type), the frequency and dosage of PE, the changes of indicators before and after PE, the adverse reactions related to PE and the prognosis of patients with HBV\u2010ACLF who received PE in our hospital from April 2018 to December 2021 were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>197 patients with HBV\u2010ACLF who underwent PE were included in the analysis. Multivariate analysis shows that blood ammonia, ALBI, bacterial infection rate, HBV\u2010DNA load, MELD score, etc., are independent risk factors affecting the efficacy of PE treatment in HBV\u2010ACLF patients before and after PE treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are many factors influencing the efficacy of plasma exchange in patients with HBV\u2010ACLF. Compared to other factors, high blood ammonia levels and high ALBI are the independent risk factors for poor short\u2010term efficacy of plasma exchange.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70729","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T05:34:03Z","timestamp":1745300043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Plasma Exchange on Hepatitis B\u2010Related Acute\u2010On\u2010Chronic Liver Failure: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Clinical Laboratory, The People's Hospital of Danyang Danyang Hospital Affiliated to Nantong University Danyang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Song","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, The People's Hospital of Danyang Danyang Hospital Affiliated to Nantong University Danyang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-2580","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, The People's Hospital of Danyang Danyang Hospital Affiliated to Nantong University Danyang Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.09.001"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"1","article-title":"Risk Factors of Invasive Pulmonary Fungal Infections in Patients With Hepatitis B Virus Related Acute\u2010on\u2010Chronic Liver Failure","volume":"2021","author":"He Xinchun T. 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