{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:09:38Z","timestamp":1788480578741,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Innovative advancements in cardiopulmonary bypass (CPB) configurations, such as surface coating, blood filtration, and miniaturization, aim to reduce gaseous microemboli (GME) that contribute to embolic organ damage, particularly neurological dysfunction. Arterial line filters are effective in mitigating embolism risk. Neurological complications post\u2010cardiac surgery can result from reduced cerebral blood flow, embolic materials, and other factors, including anesthesia. This study evaluates the impact of integrated arterial filter oxygenator (IAF\u2010Oxy.) versus external arterial filters (EAF) on clinical outcomes in pediatric patients undergoing surgery for congenital heart disease (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective randomized controlled trial included 100 pediatric patients undergoing cardiac surgery under CPB. Patients were randomized into two groups: Group A included external arterial filters (EAF) with membrane oxygenators such as Capiox Baby RX 05 and others, while Group B included integrated arterial filters (IAF) with oxygenators like Capiox Baby FX 05. The outcomes were neurological function, mechanical ventilation time (hours), intensive care unit stay (hours), and hospital stay (days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Group B demonstrated significantly lower mean aortic cross\u2010clamp (70.2\u2009\u00b1\u200938.5 vs. 88.0\u2009\u00b1\u200949.7\u2009min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and CPB times (104\u2009\u00b1\u200948.1 vs. 128\u2009\u00b1\u200966\u2009min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Postoperative FOUR scores were identical (16 out of 16) in both groups. Median ventilation time (26.5 [24.25\u2013125.25]\u2009hours\u00a0in Group A vs. 25.0 [12.0\u201350.0] hours in Group B;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.258), CSICU stay (120.0 [72.0\u2013216.0]\u2009hours in Group A vs. 108.0 [72.0\u2013162.0] hours in Group B;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.358), and hospital stay (13\u2009\u00b1\u200911 days in Group A vs. 10\u2009\u00b1\u20095 days in Group B;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.138) were comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Integrated arterial filter oxygenator may serve as an alternative to external arterial filters, potentially reducing gaseous microemboli. IAF\u2010Oxy. could improve clinical outcomes, reduce CSICU and hospital stays, and enhance care for pediatric congenital heart disease (CHD) patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70741","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:25:18Z","timestamp":1747639518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Integrated Arterial Filter Oxygenator vs. External Arterial Filters on Clinical Outcomes and Neurocognitive Function in Pediatric Cardiac Surgery: A Prospective Randomized Controlled Trial (RCT)"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-4315","authenticated-orcid":false,"given":"Vishal Vinayak","family":"Bhende","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Bhanubhai and Madhuben Patel Cardiac Centre Shree Krishna Hospital, Bhaikaka University Karamsad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-3165","authenticated-orcid":false,"given":"Mathangi","family":"Krishnakumar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology St. John's Medical College Hospital Bengaluru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-6542","authenticated-orcid":false,"given":"Dushyantkumar Mukundbhai","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Perfusion Technology, Bhanubhai and Madhuben Patel Cardiac Centre Shree Krishna Hospital, Bhaikaka Univesity Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4964-3228","authenticated-orcid":false,"given":"Arunkumar Ghanshyambhai","family":"Rudakiya","sequence":"additional","affiliation":[{"name":"Department of Perfusion Technology, Bhanubhai and Madhuben Patel Cardiac Centre Shree Krishna Hospital, Bhaikaka Univesity Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-8160","authenticated-orcid":false,"given":"Tanishq Shashikant","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, Bhanubhai and Madhuben Patel Cardiac Centre Shree Krishna Hospital, Bhaikaka University Karamsad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8950-4448","authenticated-orcid":false,"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Intensive Care, Bhanubhai and Madhuben Patel Cardiac Centre, Shree Krishna Hospital Bhaikaka University Karamsad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-5314","authenticated-orcid":false,"given":"Paresh Dilip","family":"Nerurkar","sequence":"additional","affiliation":[{"name":"Department of Perfusion Technology, Bhanubhai and Madhuben Patel Cardiac Centre Shree Krishna Hospital, Bhaikaka Univesity Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8796-1995","authenticated-orcid":false,"given":"Saptak Piyush","family":"Mankad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dev Medical Hospital Vadodara Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-0800","authenticated-orcid":false,"given":"Mamta Roshan","family":"Patel","sequence":"additional","affiliation":[{"name":"Biostatistician, Central Research Services Bhaikaka University Karamsad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.249789A"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2008.176479"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2010.01062.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.158709"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(98)00967-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1010-7940(96)80339-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0967-2109(02)00016-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20611"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"27","article-title":"Evidence\u2010Based Used, yet Still Controversial: The Arterial Filter","volume":"44","author":"De Somer F.","year":"2012","journal-title":"Journal of Extra\u2010Corporeal Technology"},{"issue":"15","key":"e_1_2_11_11_1","first-page":"1","article-title":"Effect of Open Heart Surgery on Intellectual Function","volume":"15","author":"Aberg T.","year":"1974","journal-title":"Scandinavian Journal of Thoracic and Cardiovascular Surgery. Supplementum"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/201345156"},{"key":"e_1_2_11_13_1","volume-title":"Guidance for Cardiopulmonary Bypass Arterial Line Blood Filter 510(k) Submissions; Final Guidance for Industry and FDA","year":"2000"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(10)63890-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659115616179"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13404"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659110380773"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/529087"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/200537201"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659115621614"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200109000-00003"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1010-7940(02)00372-x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.03.032"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.70741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:04:14Z","timestamp":1763726654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.70741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/hsr2.70741"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.70741","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70741"}}