{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:53:02Z","timestamp":1787698382629,"version":"build-2784847793"},"reference-count":91,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>C\u2010reactive protein (CRP) is an inflammatory biomarker, implicated in the pathogenesis of atherosclerotic lesion formation, plaque rupture, and coronary thrombosis. The relationship between preprocedural CRP levels and subsequent development of in\u2010stent restenosis (ISR) after percutaneous coronary intervention (PCI) however remains uncertain. Against this background, we performed a systematic review and meta\u2010analysis, investigating the association between baseline CRP levels and the incidence of ISR after PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Relevant published studies were identified following a PubMed, EMBASE, MEDLINE, Scopus and Web of Knowledge databases search until April 30, 2024. To be included, studies had to be original research with: (i) angiographically determined ISR group, (ii) angiographically or clinically determined no\u2010ISR group, and (iii) CRP levels measured before the index PCI procedure for both groups. The mean difference in baseline CRP levels and associated 95% confidence interval (CI) between the ISR and no\u2010ISR groups was ascertained for each included study. The pooled standard mean difference (SMD) and its 95% CI was derived after pooling study\u2010level results using a random effects model, employing a\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010test. Begg's funnel plots and Egger's test were used for publication bias assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of a total of 1018 unique results, 19 studies, with a total sample size of 4744 patients (1154 restenosis cases\/3590 controls), were included for quantitative synthesis. ISR group had higher baseline CRP levels (SMD\u2009=\u20090.41, 95% CI\u2009=\u20090.16, 0.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) in comparison to the no\u2010ISR group. No evidence of publication bias was detected either visually by Begg's funnel plots or by Egger's test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). Our leave\u2010one\u2010out sensitivity analysis further attested our obtained associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present systematic review and meta\u2010analysis suggests a significant association of elevated pre\u2010PCI CRP with subsequent angiographically confirmed ISR. These results warrant further validation in dedicated large cohorts, ideally in a prospective setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70757","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T23:54:47Z","timestamp":1745970887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pre\u2010Percutaneous Coronary Intervention C\u2010Reactive Protein Levels and In\u2010Stent Restenosis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-1934","authenticated-orcid":false,"given":"Himanshu","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute (CVRI) Dublin Mater Private Network Dublin Ireland"},{"name":"School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renitha","family":"Reddi","sequence":"additional","affiliation":[{"name":"School of Medicine RCSI University of Medicine and Health Sciences Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Coughlan","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute (CVRI) Dublin Mater Private Network Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Durand","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute (CVRI) Dublin Mater Private Network Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-9990","authenticated-orcid":false,"given":"Daniel","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute (CVRI) Dublin Mater Private Network Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roisin","family":"Colleran","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute (CVRI) Dublin Mater Private Network Dublin Ireland"},{"name":"School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-6393","authenticated-orcid":false,"given":"Robert A.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute (CVRI) Dublin Mater Private Network Dublin Ireland"},{"name":"School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2298\/JSC140617088P"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV17I5A60"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.02.042"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.3.1310"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjopen\/oead083"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.649939"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.876763"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M07_04"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010679"},{"issue":"1","key":"e_1_2_11_12_1","first-page":"49","article-title":"Impact of C\u2010Reactive Protein on In\u2010Stent Restenosis: A Meta\u2010Analysis","volume":"37","author":"Li J. 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