{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:50:31Z","timestamp":1765547431189,"version":"3.48.0"},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The link between circulating inflammatory proteins and perianal abscess remains uncertain. This study utilized the Mendelian randomization approach to examine the potential causality of 91 circulating inflammatory proteins in relation to perianal abscess (PA) and assessed the bidirectionality of these causal effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted analyses using Genome\u2010wide Association Studies (GWAS) summary statistics for 91 circulating inflammatory proteins, sourced from 11 cohorts with a combined total of 14,824 participants. Genetic associations for PA were taken from the FinnGen Consortium R9 data, consisting of 2595 PA cases and 301,931 control individuals. Two\u2010sample Mendelian randomization (MR) analysis was utilized to investigate the causal links between these inflammatory proteins and PA. To validate the reliability of our MR findings, sensitivity analyses were carried out. Furthermore, reverse Mendelian randomization was employed to assess whether there is evidence for a reciprocal causal effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Employing the inverse\u2010variance weighted (IVW) approach, our findings identified 7 circulating inflammatory proteins with a potential causal link to PA. Notably, increased levels of interleukin\u201018 receptor 1 (OR\u2009=\u20091.10, 95% CI 1.01\u20131.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039), interleukin\u201033 (OR\u2009=\u20091.31, 95% CI 1.10\u20131.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), interleukin\u20107 (OR\u2009=\u20091.32, 95% CI 1.06\u20131.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), and tumor necrosis factor ligand superfamily member 12 (OR\u2009=\u20091.16, 95% CI 1.01\u20131.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) showed associations with increased risk for PA. Conversely, higher levels of T\u2010cell surface glycoprotein CD6 isoform (OR\u2009=\u20090.81, 95% CI 0.68\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), interleukin\u20102 (OR\u2009=\u20090.80, 95% CI 0.66\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), and programmed cell death 1 ligand 1 (OR\u2009=\u20090.84, 95% CI 0.70\u20131.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) appeared to have protective effects against this condition. Additionally, our analysis has not found any evidence to suggest a reverse causal relationship between PA and the 7 specific inflammatory factors studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our Mendelian randomization analysis identifies a probable causal association involving 91 circulating inflammatory proteins and the risk of PA development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70803","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T01:44:36Z","timestamp":1748569476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unveiling the Intricate Causal Nexus Between 91 Circulating Inflammatory Proteins and Perianal Abscess Through a Comprehensive Bidirectional Two\u2010Sample Mendelian Randomization Analysis"],"prefix":"10.1002","volume":"8","author":[{"given":"Zehui","family":"Wang","sequence":"first","affiliation":[{"name":"Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Chen","sequence":"additional","affiliation":[{"name":"Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-5869","authenticated-orcid":false,"given":"Hongshuo","family":"Shi","sequence":"additional","affiliation":[{"name":"Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3333-244X","authenticated-orcid":false,"given":"Xuecheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.12998\/wjcc.v7.i14.1795"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1055\/s-0031-1272819"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1007\/s10151-019-02144-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1016\/j.gtc.2013.08.003"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1136\/bmj.j475"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"24","article-title":"Benign Anorectal Conditions: Evaluation and Management","volume":"101","author":"Cohee M. 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