{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:18:56Z","timestamp":1763727536201,"version":"3.45.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The recommended dosing regimens for oral misoprostol in labor induction include 25\u2009\u03bcg every 2\u2009h and 50\u2009\u03bcg every 4\u2009h. However, there is no specific protocol for these regimens at Shahid Akbarabadi Hospital. This study aimed to assess the safety and effectiveness of the two dosing protocols for labor induction in women with premature rupture of membranes (PROM) and establish a tailored protocol to minimize maternal and neonatal complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial was conducted at Shahid Akbarabadi Hospital from 2021 to 2023, including pregnant women with term singleton pregnancies and confirmed PROM. Participants were randomly assigned to receive either 25\u2009\u03bcg of oral misoprostol every 2\u2009h (up to 12 doses) or 50\u2009\u03bcg every 4\u2009h (up to 6 doses). The primary outcome was the mode of delivery. Secondary outcomes included induction\u2010to\u2010delivery time, uterine tachysystole, postpartum hemorrhage, and neonatal complications. Statistical analysis was performed using chi\u2010square and\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests for comparisons between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 400 women were enrolled, with 200 in each group. The mean induction\u2010to\u2010delivery interval was significantly shorter in the 50\u2009\u03bcg group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Uterine tachysystole and postpartum hemorrhage due to atonia were more frequent in the 25\u2009\u03bcg group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The rates of cesarean and instrumental deliveries did not differ significantly between groups. The mean\u2009\u00b1\u2009SD age was 27.1\u2009\u00b1\u20095.27 years in the 25\u2009\u03bcg group and 26.8\u2009\u00b1\u20095.11 years in the 50\u2009\u03bcg group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.639).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both dosing regimens of oral misoprostol were effective for labor induction, but the 50\u2009\u03bcg dose was associated with a shorter induction\u2010to\u2010delivery time. The findings suggest that adjusting the misoprostol dosage may reduce complications.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration Code:<\/jats:bold>\n                      IRCT20221123056587N1.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70817","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T10:31:05Z","timestamp":1746441065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Safety and Effectiveness of Labor Induction With 25\u2009\u03bcg Versus 50\u2009\u03bcg of Oral Misoprostol in Women With Premature Rupture of Membranes: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"8","author":[{"given":"Erfane","family":"Ebadi","sequence":"first","affiliation":[{"name":"Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU) School of Medicine, Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-2421","authenticated-orcid":false,"given":"Maryam","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU) School of Medicine, Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Firoozabadi Clinical Research Unit (FACRU) School of Medicine, Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mazloomi","sequence":"additional","affiliation":[{"name":"Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU) School of Medicine, Iran University of Medical Sciences Tehran 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