{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:10:56Z","timestamp":1765512656900,"version":"3.48.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Pressure ulcers (PU) are injuries to the skin and underlying tissue that can have significant morbidity with the presence of complications such as dehiscence and necrosis. ClimateCare is a mattress coverlet system that aims to maintain optimal skin moisture, temperature, and humidity levels at the interface between the patient and the surface to mitigate pressure ulcer risk factors. The objective of this study is to evaluate the effectiveness of ClimateCare in improving wound outcomes and minimizing complications of pressure ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with a stage III\/IV pressure ulcer admitted for surgical closure were included in the randomized\u2010controlled trial. All patients received the Fluid Immersion Simulation (FIS) System, either with or without the ClimateCare treatment based on a convenience sampling method. The subjects were monitored for 14 days post\u2010closure (POD\u201014) for assessment of wound status and complications, including moisture, maceration, drainage, dehiscence, epidermolysis, necrosis, and demarcation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 32 patients completed the study, where 18 patients received the ClimateCare treatment and 14 patients did not. In the control group, 71% of patients had complications while 17% had complications in the ClimateCare group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). In addition, 33% of patients without the ClimateCare had open wounds, while no patients who received ClimateCare treatment had open wounds (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Patient acceptability regarding treatment comfort, difficulty with mobilization, and pain at surgical site were not significantly different between ClimateCare and control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that the ClimateCare treatment in conjunction with the FIS may be effective in decreasing risk of postoperative complications and emphasize the importance of moisture control and pressure offloading in patients. Future studies should be conducted to characterize the effects of ClimateCare in minimizing the risk of complications following wound closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70846","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:27:01Z","timestamp":1750649221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective, Single\u2010Center Trial Evaluating the Effectiveness of ClimateCare in the Acute Postoperative Management of Pressure Ulcers"],"prefix":"10.1002","volume":"8","author":[{"given":"Stuti P.","family":"Garg","sequence":"first","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-8433","authenticated-orcid":false,"given":"Anitesh","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krish V.","family":"Shah","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Hanna","sequence":"additional","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve L.","family":"Putnam","sequence":"additional","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Bai","sequence":"additional","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Griffin","sequence":"additional","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-6483","authenticated-orcid":false,"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.101287"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.155260"},{"issue":"5","key":"e_1_2_9_4_1","first-page":"539","article-title":"Pressure Sores\u2010\u2010A Multifaceted Approach to Prevention and Treatment","volume":"154","author":"Staas WE Jr","year":"1991","journal-title":"Western Journal of Medicine"},{"issue":"10","key":"e_1_2_9_5_1","first-page":"1186","article-title":"Pressure Ulcers: Prevention, Evaluation, and Management","volume":"78","author":"Bluestein D.","year":"2008","journal-title":"American Family Physician"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0997-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13031"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198105000-00009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13133"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2018.09.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12877"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2012.0412"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S24752"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.09.45"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2016.0697"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12877"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2018.09.010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-2011-0590"},{"issue":"3","key":"e_1_2_9_20_1","first-page":"171","article-title":"A New Method to Evaluate the Softening Effect of Cosmetic Ingredients on the Skin","volume":"35","author":"Takahashi M.","year":"1984","journal-title":"Medicine, Materials Science, Chemistry"},{"issue":"4","key":"e_1_2_9_21_1","first-page":"453","article-title":"The Biomechanical Properties of Skin","volume":"1","author":"Wilkes G. 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