{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:17:37Z","timestamp":1774048657090,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Keloids are challenging lesions to manage due to their resistance to treatment and high recurrence rates. This study evaluated the efficacy of an intralesional injection combining triamcinolone acetonide, 5\u2010fluorouracil, and hyaluronidase compared with triamcinolone monotherapy in treating keloids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010blinded clinical trial involved 16 participants, block\u2010randomized into two groups. The intervention group received intralesional injections of triamcinolone acetonide (0.2\u2009cc of 40\u2009mg\/cc solution), 5\u2010fluorouracil (0.4\u2009cc of 250\u2009mg\/5cc vial), and hyaluronidase (0.2\u2009cc equivalent to 300\u2009IU). The control group received triamcinolone acetonide (0.2\u2009cc of 40\u2009mg\/cc solution) with 0.6\u2009cc lidocaine of 2%. Keloid characteristics were assessed before treatment, after three injections at 3\u20134\u2010week intervals, and 2 months posttreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant improvements were observed in both groups. However, the intervention group showed greater reductions in lesion height, pliability, and modified Vancouver scar scale scores compared to the control group. No complications resulted from our interventional injection during the study period, while telangiectasia occurred with triamcinolone monotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that triple therapy was as effective as steroid monotherapy, with better outcomes in specific aspects of scar improvement and without side effects. Hyaluronidase could be promising for further research in this area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70883","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T01:39:47Z","timestamp":1748309987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unlocking Better Keloid Treatment: Corticosteroid, 5\u2010Fluorouracil, and Hyaluronidase vs. Corticosteroid Alone \u2013 A Randomized Comparative Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Ala","family":"Ehsani","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1999-7703","authenticated-orcid":false,"given":"Fatemeh","family":"Lotfi","sequence":"additional","affiliation":[{"name":"School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-4840","authenticated-orcid":false,"given":"Alireza","family":"Firooz","sequence":"additional","affiliation":[{"name":"Center for Research &amp; Training in Skin Diseases &amp; Leprosy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-1163","authenticated-orcid":false,"given":"Amirhoushang","family":"Ehsani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-7898","authenticated-orcid":false,"given":"Zahra","family":"Razavi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8586-2432","authenticated-orcid":false,"given":"Mahshid Sadat","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-2968","authenticated-orcid":false,"given":"Pedram","family":"Nourmohammadpour","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Sima","sequence":"additional","affiliation":[{"name":"Students' Scientific Research Center (SSRC) Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-4604","authenticated-orcid":false,"given":"Mina","family":"Koohian Mohammadabadi","sequence":"additional","affiliation":[{"name":"School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-4930","authenticated-orcid":false,"given":"Amirhossein","family":"Rahimnia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center, Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14920"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01810"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15159"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030606"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3923"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12803"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1914307"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1328-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00031"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.01.013"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14314"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-020-01721-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90790-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712590903490382"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.25289\/ML.2022.11.1.1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051830"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08165.x"},{"issue":"11","key":"e_1_2_11_20_1","first-page":"31","article-title":"A Novel Triple Medicine Combination Injection for the Resolution of Keloids and Hypertrophic Scars","volume":"7","author":"Goyal N. 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