{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:10:51Z","timestamp":1765512651161,"version":"3.48.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Radiofrequency ablation (RFA) has emerged as a promising minimally invasive technique for eliminating intraepithelial neoplasia (IEN). We reviewed current evidence investigating the role of RFA in managing different types of IEN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted to assess the current evidence for the use of RFA in managing various types of IEN. A three\u2010step search strategy was employed, involving keyword extraction, comprehensive database searching (PubMed, Scopus, Web of Science, Embase, and Google Scholar), and reference screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010two articles were included in this review, and most of the literature reported the features of RFA in the esophagus\u2010related IENs (68.7%). RFA treatment was also found to effectively address gastric (9.3%), anal (12.5%), and cervical (9.3%) IENs. The general opinion on using RFA in Barrett's esophagus (BE) was its combination therapy with the endoscopic mucosal resection (EMR) methods, which suggested better outcomes than RFA\/EMR monotherapy. RFA was not preferred treatment for high\u2010grade gastric dysplasia, but it was effective for the low\u2010grade type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As a minimally invasive, safe, and effective procedure, RFA holds promise for addressing lesions associated with BE, gastric, anal, and cervical IEN; However, the scope and gaps related to RFA therapy require to be explored precisely.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70938","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:30:03Z","timestamp":1750649403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiofrequency Ablation as an Alternative and Novel Procedure in the Intraepithelial Neoplasia Management: A Systematic Scoping Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-1385","authenticated-orcid":false,"given":"Hamid","family":"Reihani","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-8387","authenticated-orcid":false,"given":"Sepehr","family":"Ebrahimi\u2010Dehkordi","sequence":"additional","affiliation":[{"name":"Student Research Committee Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Moshfeghinia","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirhossein","family":"Ghiasi\u2010Nejad","sequence":"additional","affiliation":[{"name":"Student Research Committee Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiarash","family":"Noorizadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1212-1171","authenticated-orcid":false,"given":"Reza","family":"Heidari\u2010Soureshjani","sequence":"additional","affiliation":[{"name":"Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"314","article-title":"Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development","volume":"8","author":"O'Shaughnessy J. 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