{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:08:21Z","timestamp":1784549301406,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Vitamin D deficiency is a major public health issue, with varying individual responses to supplementation. Genetic factors, especially single\u2010nucleotide polymorphisms (SNPs) in Vitamin D metabolism genes, likely play a key role. This protocol proposes a systematic review to explore how genetic variability affects serum 25\u2010hydroxyvitamin D [25(OH)D] levels after supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This protocol adheres to the Preferred Reporting Items for Systematic Review and Meta\u2010Analysis Protocols (PRISMA\u2010P). The literature search will be conducted across MEDLINE, Scopus, Web of Science, and Embase, without restrictions on publication date or language. The study selection will be guided by Population, Exposure, Comparator, Outcomes, Study Design (PECOS) framework, focusing on randomized clinical trials that report pre\u2010 and post\u2010supplementation serum 25(OH)D levels alongside genotype data. Inclusion criteria comprise adults and elderly individuals, from both sexes and any ethnicity, who received Vitamin D supplementation and have SNPs data, while exclusion criteria reject studies with confounding factors such as pre\u2010existing conditions or use of medications affecting Vitamin D status. Data extraction will include study characteristics, participant demographics, intervention details, SNPs, and serum 25(OH)D data. Inter\u2010rater reliability will be assessed using Cohen's kappa coefficient. A descriptive synthesis will summarize the findings, and if feasible, a meta\u2010analysis will be conducted. The primary outcome will be changes in serum 25(OH)D concentrations. Heterogeneity among studies will be quantified using the\n                      <jats:italic>I<\/jats:italic>\n                      \u00b2 statistic. The methodological quality of studies will be assessed using the Joanna Briggs Institute checklist, and the overall certainty of evidence will be evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>By identifying genetic subgroups with differential responses to vitamin D supplementation, the findings are expected to contribute to the development of personalized supplementation strategies. These insights may enhance health interventions by optimizing supplementation protocols based on genetic predispositions, ultimately improving health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This protocol has been registered with International prospective register of systematic reviews (PROSPERO) ID: CRD42023449836.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70948","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:05:04Z","timestamp":1757574304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Polymorphisms in Genes Related to Vitamin D Metabolism on Serum Response to Supplementation in Adults and Elderly: A Systematic Review and Meta\u2010Analysis Protocol"],"prefix":"10.1002","volume":"8","author":[{"given":"Lana Pacheco","family":"Franco\u2010Gedda","sequence":"first","affiliation":[{"name":"Nutritional Genomics Research Group, Faculty of Nutrition Universidade Federal de Goi\u00e1s (UFG) Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Nutritional Genomics Research Group, Faculty of Nutrition Universidade Federal de Goi\u00e1s (UFG) Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Noll","sequence":"additional","affiliation":[{"name":"Instituto Federal Goiano (IF Goiano) Ceres Goi\u00e1s Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-4198","authenticated-orcid":false,"given":"Marcela Moraes","family":"Mendes","sequence":"additional","affiliation":[{"name":"Nutritional Genomics 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