{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:16:09Z","timestamp":1764479769677,"version":"3.46.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Sensorineural hearing loss (SNHL) is a common hearing disorder prevalent.\n                      <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                      (\n                      <jats:italic>B. burgdorferi<\/jats:italic>\n                      ) is a spirochete whose infection has been shown to result in SNHL. This systematic review aims to investigate the prevalence and association of\n                      <jats:italic>B. burgdorferi<\/jats:italic>\n                      infection in SNHL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic literature search on the databases Medline, Google Scholar, and UpToDate was performed. The study selection process was done in accordance with the PRISMA guideline. In brief, studies were selected first by title and abstract screening followed by a full\u2010text inspection. The study was included if the study reported the incidence of\n                      <jats:italic>B. burgdorferi<\/jats:italic>\n                      infection in patients with SNHL. The quality assessment of the included studies was performed using the Joanna Briggs Institute Critical Appraisal tool. Data on study characteristics, patient demographics, audiological, microbiological, symptomatological, and therapeutical findings were extracted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study search retrieved a total of 8772 studies and 9 of them met out eligibility requirement. There were altogether 964 SNHL patients. In total, 71 (7.3%) were tested positive for\n                      <jats:italic>B. burgdorferi<\/jats:italic>\n                      infection. The commonest symptoms in infected SNHL patients were tinnitus (53%) and vertigo (47%). Patients treated with steroids along with ceftriaxone showed a higher hearing recovery rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>B. burgdorferi<\/jats:italic>\n                      infection is prevalent among patients with SNHL and should be investigated whenever no other reasons of hearing loss are established.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70974","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:16:04Z","timestamp":1751328964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Borrelia burgdorferi<\/i>\n                    Infection Is Worth Screening to Investigate Sensorineural Hearing Loss Etiology: A Systematic Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2232-4124","authenticated-orcid":false,"given":"Abhinav","family":"Bhattarai","sequence":"first","affiliation":[{"name":"Institute of Medicine Tribhuvan University Kathmandu Nepal"},{"name":"Medical Database Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-3329","authenticated-orcid":false,"given":"Sangam","family":"Shah","sequence":"additional","affiliation":[{"name":"Institute of Medicine Tribhuvan University Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-1082","authenticated-orcid":false,"given":"Madhur","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Institute of Medicine Tribhuvan University Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garima","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Institute of Medicine Tribhuvan University Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunraj","family":"Tharu","sequence":"additional","affiliation":[{"name":"Institute of Medicine Tribhuvan University Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandira","family":"Khadka","sequence":"additional","affiliation":[{"name":"Maharajgunj Nursing Campus Tribhuvan University Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Sharma","sequence":"additional","affiliation":[{"name":"Institute of Medicine Tribhuvan University Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Kharel","sequence":"additional","affiliation":[{"name":"Institute of Medicine Tribhuvan University Kathmandu 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