{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:44:58Z","timestamp":1785361498839,"version":"3.55.0"},"reference-count":143,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD), a chronic neurodegenerative disorder, is portrayed by neurocognitive decline in the structure and function of the human brain. Various factors are implicated in the pathogenesis to neuroplasticity alteration in the brain of an individual afflicted with AD. The subset of these elements known as \u201chormonal dynamics\u201d is paramount in the pathophysiology of AD. This review dives into the complex relationship between hormonal dynamics and brain neuroplasticity with special handling of AD considering the impediments and opportunities for the implementation of therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive review was conducted using online search databases PubMed\/Medline and ScienceDirect, identifying\u2014with a thematic approach\u2014articles handling the interaction between the hormonal fluctuation and neuroplasticity in AD with special consideration sought from the emerging therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review reveals the influence of various hormonal fluctuations, including estrogens and androgens, on neuroplasticity alteration in the structure and function of the brain in AD. Furthermore, the forms of neuroplasticity and synaptic plasticity processes are significantly altered with underlying neuronal loss and cognitive impairment in AD. Therefore, pharmacological and nonpharmacological therapy approaches as virtual reality and repetitive transcranial magnetic stimulation (rTMS), that promote synaptic plasticity advancements, play a key role in decreasing the rate of deterioration and progression in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Apprehending the intricate interactions between hormonal dynamics and neuroplasticity of the brain is necessary for advancing targeted therapeutics for AD. Upcoming studies should be directed toward the pathophysiological mechanism of hormonal neuroprotection and regeneration with the long\u2010term effects of hormonal replacement therapies, advocating personalized management plans. It should also work on identifying specific imaging and biological markers for the monitoring of HRT. Furthermore, other influences such as environmental, epigenetic, physical, and psychological illness should be tackled.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70975","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T16:04:34Z","timestamp":1752077074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Understanding the Intersection Between Hormonal Dynamics and Brain Plasticity in Alzheimer's Disease: A Narrative Review for Implementing New Therapeutic Strategies"],"prefix":"10.1002","volume":"8","author":[{"given":"Abir","family":"Ghosson","sequence":"first","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization, Research and Education Kigali Rwanda"},{"name":"Faculty of Medicine Beirut Arab University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Soufan","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization, Research and Education Kigali Rwanda"},{"name":"Faculty of Medicine Beirut Arab University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Kaddoura","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization, Research and Education Kigali Rwanda"},{"name":"Faculty of Medicine Beirut Arab University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa","family":"Fares","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization, Research and Education Kigali Rwanda"},{"name":"Faculty of Medicine Beirut Arab University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-9027","authenticated-orcid":false,"given":"Olivier","family":"Uwishema","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization, Research and Education Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16049"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14506.1"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8363245"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010107"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3934\/Neuroscience.2021020"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e31826a998d"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101660"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10639"},{"key":"e_1_2_16_14_1","volume-title":"StatPearls","author":"Puderbaugh M.","year":"2024"},{"key":"e_1_2_16_15_1","unstructured":"\u201cHow Brain Neurons Change Over Time From Life Experience \u201d Verywell Mind [accessed March 28 2024] https:\/\/www.verywellmind.com\/what-is-brain-plasticity-2794886."},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301559"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005507"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00204"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.11.029"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.70025"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16360"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43053"},{"key":"e_1_2_16_23_1","unstructured":"\u201cSteroid Hormones: Risk and Resilience in Women's Alzheimer Disease \u201d Frontiers [accessed January 3 2025] https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2023.1159435\/full."},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2018.25.4.3"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0122-6"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1286066"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.05.054"},{"key":"e_1_2_16_28_1","doi-asserted-by":"crossref","unstructured":"\u201cEstrogen Receptors: A New Frontier in Alzheimer's Disease Therapy \u201d [accessed January 3 2025] https:\/\/www.mdpi.com\/1422-0067\/25\/16\/9077.","DOI":"10.3390\/ijms25169077"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043205"},{"key":"e_1_2_16_30_1","unstructured":"\u201cAssociation of Age at Menopause and Hormone Therapy Use With Tau and \u03b2\u2010Amyloid Positron Emission Tomography \u201dJAMA Neurology [accessed January 3 2025] https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2802791."},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318271f823"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.24.2947"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.029"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.12.007"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09867"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.2741\/E434"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.210175"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.586909"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.02.968"},{"key":"e_1_2_16_40_1","doi-asserted-by":"crossref","unstructured":"\u201cSex and Gender Differences in Cognitive Resilience to Aging and Alzheimer's Disease \u201dAlzheimer's & Dementia(2024) https:\/\/doi.org\/10.1002\/alz.13844.","DOI":"10.1002\/alz.13844"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980-57642011DN05010003"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-23-01403"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12232726"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12948"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0727"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13211793"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3540-2_9"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.2.4.6354"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11010011"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2015"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S173970"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-18-07084.2003"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051236"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189987"},{"key":"e_1_2_16_55_1","unstructured":"\u201cInsulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells \u201d [accessed 2025 January 4 2025] https:\/\/pubmed.ncbi.nlm.nih.gov\/23239816\/."},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.011015"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-5-25"},{"key":"e_1_2_16_58_1","unstructured":"\u201cInsulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer's Disease \u201d [accessed January 4 2025] https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5575843\/."},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4772"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.01.004"},{"key":"e_1_2_16_61_1","doi-asserted-by":"crossref","unstructured":"\u201cChapter 13 \u2013 Diabetes and Cognitive Dysfunction \u201d [accessed January 4 2025] https:\/\/doi.org\/10.1016\/B978-0-12-398270-4.00013-6.","DOI":"10.1016\/B978-0-12-398270-4.00013-6"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000202"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00853-0"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26036"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000311"},{"key":"e_1_2_16_66_1","doi-asserted-by":"crossref","unstructured":"\u201cPerspective of SGLT2 Inhibition in Treatment of Conditions Connected to Neuronal Loss: Focus on Alzheimer's Disease and Ischemia\u2010Related Brain Injury \u201d [accessed January 4 2025] https:\/\/www.mdpi.com\/1424-8247\/13\/11\/379.","DOI":"10.3390\/ph13110379"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18087"},{"key":"e_1_2_16_68_1","unstructured":"National Institute on Aging Beyond the Brain: The Gut Microbiome and Alzheimer's Disease(National Institute on Aging 2023) https:\/\/www.nia.nih.gov\/news\/beyond-brain-gut-microbiome-and-alzheimers-disease."},{"key":"e_1_2_16_69_1","unstructured":"L.Hemi L.Xuan L.Liang\u2010Feng L.Min Z.Wenyong andL.Tiangang \u201cGut Microbiota\u2010Derived Bile Acids Promote Gamma\u2010Secretase Activity Through Interactions With Nicastrin Subunits \u201d preprint arXiv 2023 https:\/\/doi.org\/10.48550\/arXiv.2310.07233."},{"key":"e_1_2_16_70_1","unstructured":"\u201cWhat Role Does the Gut Microbiome Play in Why More Women Develop Alzheimer's Disease? \u201dUChicago News 2024 https:\/\/news.uchicago.edu\/story\/what-role-does-gut-microbiome-play-why-more-women-develop-alzheimers-disease."},{"key":"e_1_2_16_71_1","unstructured":"\u201cThe Estrobolome \u201dZRT Laboratory 2023 https:\/\/www.zrtlab.com\/blog\/archive\/the-estrobolome-the-bidirectional-relationship-between-gut-microbes-and-hormones\/."},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00294.2021"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1130689"},{"key":"e_1_2_16_74_1","doi-asserted-by":"crossref","unstructured":"\u201cMicrobiota Implications in Endocrine\u2010Related Diseases: From Development to Novel Therapeutic Approaches \u201d [accessed January 4 2025] https:\/\/www.mdpi.com\/2227-9059\/12\/1\/221.","DOI":"10.3390\/biomedicines12010221"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030668"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02073-3"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819410-2.00027-8"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_16_80_1","doi-asserted-by":"crossref","unstructured":"S.Meftah A.Cavallini T. K.Murray et al. \u201cSynaptic Alterations Associated With Disrupted Sensory Encoding in a Mouse Model of Tauopathy \u201d preprint bioRxiv 2023 https:\/\/doi.org\/10.1101\/2023.05.24.542163.","DOI":"10.1101\/2023.05.24.542163"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24001"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2583"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2207"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64463-X"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-48"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.05.012"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096615"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00070-1"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2023.07.004"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(91)90006-6"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030701"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20193"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088417"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2234031100"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.015"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.10.009"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.117.016261"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2758"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22389"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110647"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00151"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.10.1524"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.044"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42775-w"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-068646"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192315585"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41914"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2180-x"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.09.016"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604519113"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2018.10.009"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(85)92413-4"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.06.712"},{"key":"e_1_2_16_115_1","doi-asserted-by":"crossref","unstructured":"\u201cThe Effect of High\u2010Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing Reappraisal and Craving in Alcohol Use Disorder Patients and Healthy Controls \u201d (2024) https:\/\/doi.org\/10.3389\/fpsyt.2019.00272.","DOI":"10.3389\/fpsyt.2019.00272"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.10.003"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10081151"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.033"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.051804.101459"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00055.2003"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.81.10.8855804"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.04.008"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903360210"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.3.0365"},{"key":"e_1_2_16_125_1","doi-asserted-by":"crossref","unstructured":"L.Mosconi S.Jett M.Nerattini et al. \u201cIn Vivo Brain Estrogen Receptor Expression by Neuroendocrine Aging and Relationships With Gray Matter Volume Bio\u2010Energetics and Clinical Symptomatology \u201c preprint Research Square 2023 https:\/\/doi.org\/10.21203\/rs.3.rs-2573335\/v1.","DOI":"10.21203\/rs.3.rs-2573335\/v1"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1970-18.2019"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12050109"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.11.003"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-2236(99)01438-1"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(02)02985-2"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10207"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25152"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910666116"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14315"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.07.003"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1080\/tam.6.1.13.17"},{"issue":"3","key":"e_1_2_16_137_1","first-page":"203","article-title":"Testosterone and Gonadotropin Levels in Men With Dementia","volume":"24","author":"Hogervorst E.","year":"2003","journal-title":"Neuroendocrinology Letters"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.04.012"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.21044"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2740"},{"key":"e_1_2_16_141_1","unstructured":"\u201cVolume 101 Supplement 1 2024 \u201dJournal of Alzheimer's Disease [accessed January 4 2025] https:\/\/www.j-alz.com\/vol101-s1."},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15082052"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12102"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11010056"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.70975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:13:49Z","timestamp":1764479629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.70975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":143,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/hsr2.70975"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.70975","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70975"}}