{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:33:11Z","timestamp":1790019191135,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Functional abdominal bloating and distension disorder (FABD) is a single\u2010syndrome gastrointestinal disorder of the \u201cgut\u2013brain axis,\u201d and is associated with a negative impact on adult's well\u2010being. Abdomino\u2010phrenic dyssynergia has recently been recognized as an important contributing factor to FABD, yet the influence of other spinal musculoskeletal determinants of this gastrointestinal disorder is not known. Our aim was to qualitatively explore spinal musculoskeletal determinants and propose research on potential new treatments for FABD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this narrative review, observational and intervention studies describing terminology, proposed pathophysiology, and interventions with focus on modifiable musculoskeletal determinants of FABD were reviewed from inception through 2023. Databases of PubMed, Scopus, Google Scholar, and ISI Web of Science were searched using the following keywords: \u201cfunctional abdominal bloating,\u201d \u201cabdominal bloating,\u201d spine,\u201d Abdomino\u2010phrenic dyssynergia,\u201d \u201cabdominal wall,\u201d \u201cpelvic floor,\u201d \u201cback extensor muscle.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review included 65 studies. These studies were explored in three sections: Abdomino\u2010phrenic dyssynergia, pelvic floor function, and sagittal alignment of spine. Although most of included articles reported APD as the main contributing factor to FABD, other spinal\u2010related musculoskeletal factors, abdominal muscle weakness, pelvic floor dyssynergia, and spinal malalignments were considered. These musculoskeletal factors were reviewed as both evidence of FABD (direct evidence) and other disorder of gut\u2013brain interactions (DGBIs) (indirect evidence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preliminary evidence suggests spinal musculoskeletal factors contribute to FABD; however, more high\u2010quality observational studies exploring relationships between FABD and spinal\u2010based musculoskeletal factors are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70976","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T16:10:15Z","timestamp":1752077415000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spinal\u2010Related Musculoskeletal Determinants of Functional Abdominal Bloating and Distension: A Narrative 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