{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:34:51Z","timestamp":1784007291976,"version":"3.55.0"},"reference-count":77,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Antiseptics have been widely used in periodontology and implantology as an adjunct to mechanical plaque control. The main objective of this review was to summarize the best evidence for the use of antiseptics in the prevention and treatment of periodontal and peri\u2010implant diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted across multiple databases, including Scopus, PubMed\/Medline, Web of Science, and ScienceDirect. Keywords such as (Antiseptics OR mouthwashes) AND (gingivitis OR periodontitis OR peri\u2010implantitis OR mucositis) were used. Inclusion criteria included narrative or systematic reviews with or without meta\u2010analysis and clinical studies. In vitro, animal studies, and case reports were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Antiseptics, including chlorhexidine, essential oils, and povidone\u2010iodine, proved effective in reducing gingival inflammation and improving the plaque index. Other molecules, such as octenidine dihydrochloride, showed some effectiveness, although further studies are needed to expand their use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antiseptics play a crucial role in improving periodontal health. Prescriptions should be tailored to therapeutic goals to ensure appropriate dosage and duration, while avoiding excessive use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71019","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:05:33Z","timestamp":1752062733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antiseptics Prescription for the Prevention and Treatment of Periodontal Diseases: A Comprehensive Review"],"prefix":"10.1002","volume":"8","author":[{"given":"Lamiae","family":"Costo","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Mounsif","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamiaa","family":"Abdallaoui Maan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-5467","authenticated-orcid":false,"given":"Amal","family":"Bouziane","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine Mohammed V University in Rabat Rabat Morocco"},{"name":"Laboratory of Biostatistics, Clinical Research and Epidemiology Mohammed V University in Rabat Rabat Morocco"},{"name":"Research Laboratory in Oral Biology and Biotechnology, Faculty of Dental Medicine Mohammed V University in Rabat Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12201"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_8_4_1","volume-title":"Lindhe's Clinical Periodontology and Implant Dentistry","author":"Berglundh T.","year":"2021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13091332"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8177(94)14001-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12511"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103497"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00587"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2020.01.022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0765-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083522"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098619854881"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.08.018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1379-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.26818"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03661-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2017.1260118"},{"issue":"7","key":"e_1_2_8_19_1","first-page":"211","article-title":"Effect of Herbal, Essential Oil, and Chlorhexidine Mouthrinses on the Composition of the Subgingival Microbiota and Clinical Periodontal Parameters","volume":"20","author":"Haffajee A. 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