{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:20:44Z","timestamp":1783938044018,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Urinary tract infections are among the most common infections globally, with increasing rates of antibiotic resistance complicating their management. This study aimed to determine the prevalence, bacteriological profile, and antibiotic susceptibility patterns of uropathogens isolated from urine samples at Methodist Hospital, Wenchi, Ghana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted using data on urine culture and antibiotic susceptibility testing obtained from the Microbiology Unit of the Laboratory Department between March 2024 and January 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 504 urine samples were analyzed, revealing a prevalence of urinary tract infections at 45.2%. The predominant pathogens were Gram\u2010negative bacteria, with\n                      <jats:italic>Klebsiella spp<\/jats:italic>\n                      (12.3%) and\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (10.1%) being the most frequently isolated organisms.\n                      <jats:italic>Candida spp<\/jats:italic>\n                      were also identified in 5.8% of the samples. Females accounted for 74.6% of the infections, with the highest prevalence observed among individuals aged 20\u201340 years. Antimicrobial susceptibility testing demonstrated significant resistance among bacterial isolates, with\n                      <jats:italic>Klebsiella spp<\/jats:italic>\n                      showing the highest resistance to Beta\u2010lactams and Fluoroquinolones. Amikacin exhibited the lowest resistance rate (4.4%), making it a strong candidate for empirical therapy. Multi\u2010drug resistance (MDR) was demonstrated by 72.7% of bacterial isolates, with\n                      <jats:italic>Klebsiella spp<\/jats:italic>\n                      and\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      showing the highest MDR rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The identified patterns of antimicrobial resistance highlight the critical importance of careful antibiotic selection to effectively manage urinary tract infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71029","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:00:59Z","timestamp":1752127259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antimicrobial Susceptibility Patterns of Uropathogens: A Retrospective Study at a Primary Care Hospital in Ghana"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1985-2651","authenticated-orcid":false,"given":"Samuel Kyeremeh","family":"Adjei","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Methodist Hospital Wenchi Bono Region Ghana"},{"name":"School of Public Health and Allied Sciences Catholic University of Ghana Fiapre\u2010Sunyani Bono Region Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1221-4667","authenticated-orcid":false,"given":"Prosper","family":"Adjei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Methodist Hospital Wenchi Bono Region Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801711010292"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2016153"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2743-8"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1507505"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12040623"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.26946"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2023.08.009"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/11786361221106109"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287219832172"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v16i4.31"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S204880"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afju.2016.11.005"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200894"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S342753"},{"key":"e_1_2_13_17_1","unstructured":"Africa CDC Africa\u2010CDC\u2010Framework\u2010for\u2010Antimicrobial\u2010Resistance\u2010Regional Guide for Governments in Africa 2018 https:\/\/africacdc.org\/download\/africa-cdc-framework-for-antimicrobial-resistance\/."},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_13_19_1","unstructured":"N.Sumareh Aetiologies of Urinary Tract Infection From Patients Seen at Medical Research Council Unit Fajara: The Gambia in 2013 (2014)."},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4246780"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10100832"},{"key":"e_1_2_13_22_1","first-page":"282","article-title":"Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animalsclsi Supplement VET08. 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