{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:46:05Z","timestamp":1792885565598,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      ) is a major cause of burn wound infections, posing a significant challenge due to its increasing antibiotic resistance. This study evaluated the prevalence and antibiotic resistance patterns of\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      isolates from burn patients admitted to a referral burn center in Northern Iran over 3 years (March 2018\u2013March 2021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cross\u2010sectional study was conducted on 535 samples collected from burn patients.\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      isolates were identified using standard microbiological methods and tested for susceptibility to various antibiotics through the disc diffusion method. Data analysis involved descriptive statistics to assess the prevalence and resistance patterns of the isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      accounted for 36.1% (193\/535) of bacterial isolates. The annual prevalence of\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      varied from 19.6% to 44.4%, with the highest frequency observed among patients with 26%\u201350% total body surface area burns. Skin and soft tissue infections were the most common source (75.1%), followed by bloodstream infections (15%). Notably, 62.7% of isolates originated from intensive care unit (ICU) patients. High resistance was observed against ceftazidime (80%), ciprofloxacin (77.2%), imipenem (76.6%), and meropenem (76.1%). Conversely, amikacin (78.2%) and gentamicin (45%) exhibited the highest susceptibility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The findings indicate a high prevalence of\n                      <jats:italic>Pseudomonas<\/jats:italic>\n                      with DTR, highlighting the need for stricter antibiotic stewardship and alternative treatment options. While amikacin showed higher susceptibility in our study, the recent CLSI 2023 guidelines suggest its use should be limited to urine isolates. In light of these updated recommendations, the use of aminoglycosides in treating\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      infections requires cautious evaluation. Further multicenter studies with larger sample sizes are warranted to generalize these findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71054","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T13:05:26Z","timestamp":1752843926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiological Trends and Evolving Antibiotic Resistance Profiles of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    in Burn Patients: A 3\u2010Year Cross\u2010Sectional Surveillance in Northern Iran"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-5647","authenticated-orcid":false,"given":"Mahsa","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Burn and Regenerative Medicine Research Center Guilan University of Medical Sciences Rasht Iran"},{"name":"Department of Microbiology, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Mobayen","sequence":"additional","affiliation":[{"name":"Burn and Regenerative Medicine Research Center Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tofigh","family":"Yaghubi Kalurazi","sequence":"additional","affiliation":[{"name":"Razi Clinical Research Development Unit, Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Mehrdad","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadamin Khajavi","family":"Gaskarei","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina Kamrani","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Faculty of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-5199","authenticated-orcid":false,"given":"Hadi","family":"Sedigh Ebrahim\u2010Saraie","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Guilan University of Medical Sciences Rasht Iran"},{"name":"Razi Clinical Research Development Unit, Razi Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6281-8273","authenticated-orcid":false,"given":"Meysam","family":"Hasannejad\u2010Bibalan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S213200"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(00)00106-6"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2020.100686"},{"issue":"3","key":"e_1_2_13_5_1","first-page":"202","article-title":"A Two\u2010Year Study of Microbiological Characteristics of Intravascular Catheter\u2010Related Bloodstream Infections at Razi Hospital, Iran","volume":"75","author":"Hasannejad\u2010Bibalan M.","year":"2021","journal-title":"New Zealand Journal of Medical Laboratory Science"},{"issue":"2","key":"e_1_2_13_6_1","first-page":"61","article-title":"Drug Resistance of Isolated Strains of Pseudomonas aeruginosa From Burn Wound Infections to Selected Antibiotics and Disinfectants","volume":"1","author":"Oulia P.","year":"2006","journal-title":"Iranian Journal of Pathology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/LMNIJE31EDC1WAMP"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-9946201658013"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01135"},{"issue":"2","key":"e_1_2_13_10_1","first-page":"162","article-title":"Assessment of Carbapenem Susceptibility and Multidrug\u2010Resistance in Pseudomonas aeruginosa Burn Isolates in Tehran","volume":"6","author":"Moazami G. 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Z.","year":"2015","journal-title":"Iranian Journal of Microbiology"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.18683\/germs.2017.1113"},{"issue":"4","key":"e_1_2_13_24_1","first-page":"204","article-title":"Drug Resistance of Pseudomonas aeruginosa and Enterobacter cloacae Isolated From ICU, Babol, Northern Iran","volume":"2","author":"Bayani M.","year":"2013","journal-title":"International Journal of Molecular and Cellular Medicine"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJMR11.1048"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.20130v2"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4071-0"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:14:22Z","timestamp":1764479662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/hsr2.71054"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71054","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71054"}}