{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:27:46Z","timestamp":1789961266526,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hailey\u2010Hailey disease (HHD), or familial benign chronic pemphigus, is a rare autosomal dominant genodermatosis characterized by chronic, painful, erythematous, erosive plaques and fissures at sites of friction such as the neck, axilla, groin, and perineum. The pathogenesis is due to a mutation in the ATP2C1 gene, which encodes the human secretory\u2010pathway calcium\/manganese\u2010ATPase isoform 1 (hSPCA1) that regulates calcium and manganese concentration in the Golgi apparatus. The diagnosis relies on clinical presentation and characteristic histopathological features, notably a \u201cdilapidated brick wall\u201d appearance. There is no cure for this genodermatosis and main aim of management in HHD is to control symptoms and reduce recurrence. Multitude of topical, systemic agents, procedural therapy such as laser therapy and surgery for the treatment of HHD have been reported in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This comprehensive review aims to discuss the efficacy of current HHD treatments with special focus on therapeutic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review highlights clinical and histological features of HHD and offers guidance for dermatologists involved in managing this distinct dermatosis.<\/jats:p>\n                  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