{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:17:51Z","timestamp":1789888671557,"version":"4.0.1"},"reference-count":141,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) and Parkinson's disease (PD) are progressive neurodegenerative disorders with significant cognitive and motor impairments, affecting millions globally. Current treatments offer limited efficacy, prompting the exploration of new therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To discuss the intricate relationship between incretin and insulin signaling pathways and their relevance to the pathogenesis and treatment of Alzheimer's and Parkinson's diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature review was conducted using a variety of search engines, including Google Scholar, PubMed Central, Scopus, Web of Science, and others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Emerging evidence highlights disrupted insulin signaling in AD and, to a lesser extent, in PD, suggesting that insulin plays a key neuroprotective role. Incretins, such as GLP\u20101 and GIP, which enhance insulin signaling, have shown potential in preclinical and clinical studies. Incretin\u2010based therapies, particularly GLP\u20101\/GIP receptor agonists, have demonstrated promising effects by addressing several pathological processes, including oxidative stress, inflammation, misfolded protein aggregation, and insulin resistance. Dual agonists like DA\u2010CH3, DA5\u2010CH, and DA4\u2010JC have proven superior in crossing the blood\u2010brain barrier and offering improved neuroprotection in comparison with conventional GLP\u20101 agonists. Triple agonists provide even greater neuroprotective benefits, highlighting their potential as disease\u2010modifying therapies for AD and PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While GLP\u20101 and GIP analogs hold promise in modulating early neurodegenerative processes, their efficacy likely depends on timely intervention before permanent neuronal damage occurs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71065","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T01:48:07Z","timestamp":1752716887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incretin\u2010Based Therapies in Alzheimer's and Parkinson's Disease: Advancing Neuroprotection With Dual and Triple Agonists\u2014A Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-2827","authenticated-orcid":false,"given":"Ousman","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia"},{"name":"Department of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University Dessie Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsehayneh","family":"Kelemu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.07.003"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818084-6.00004-0"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14121191"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01120-4"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_2_17_7_1","unstructured":"C.Patterson \u201cThe State of the Art of Dementia Research: New Frontiers\u201d World Alzheimer Report 2018."},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30295-3"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30355-7"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240069"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01792-4"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266293416240515075450"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.970925"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101979"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.109952"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111812"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286887"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.873301"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5764-dn-2023-0032"},{"key":"e_1_2_17_20_1","article-title":"Expanding the Understanding of Insulin Resistance in Brain and Periphery","volume":"36","author":"Chen W.","year":"2025","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050588"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-88832-9_56"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052687"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214417"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2025.102118"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140016"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2019.10.008"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01486-5"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123001"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105510"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.09.006"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3540-2_11"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.06.018"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00868"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00017"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01558-1"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33657"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70057"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30231-3"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-021-01969-5"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150813142423"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117540"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8768-0"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1840"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.003"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12959"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189987"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420188231222367"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2022.955258"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00260"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.721135"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.09.010"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.462"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000164"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011395"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.01.013"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175439"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.9b00003"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.721198"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.11.017"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.04.010"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132020"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.170184"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.01.040"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2015-0021"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.170230"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt174"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.10.002"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.050"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2022.2079492"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031170"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4229"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.09.035"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.03.059"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9101007"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01112"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.86831"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18050614"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.11.048"},{"key":"e_1_2_17_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.04.006"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.111932"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2021.107463"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111529"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00869-3"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.01.103"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.09.054"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094972"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01666-7"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114578"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101180"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020860"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3259-x"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158205"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.114"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191768"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.03.018"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00108"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17718-y"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.08.006"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.057848"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205016666190913155950"},{"key":"e_1_2_17_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01180-z"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-230181"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.912995"},{"key":"e_1_2_17_106_1","first-page":"129","volume-title":"Pharmacological Treatment of Parkinson's Disease","author":"Zahoor I.","year":"2018"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.226"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073812"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01018-5"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.98.18_supplement.3068"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28449-z"},{"key":"e_1_2_17_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1764534"},{"key":"e_1_2_17_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40290-020-00374-5"},{"key":"e_1_2_17_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1462240"},{"key":"e_1_2_17_115_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181503"},{"key":"e_1_2_17_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0051-5"},{"key":"e_1_2_17_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0548-y"},{"key":"e_1_2_17_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.09.023"},{"key":"e_1_2_17_119_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4304"},{"key":"e_1_2_17_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14096"},{"key":"e_1_2_17_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00278"},{"key":"e_1_2_17_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31585-4"},{"key":"e_1_2_17_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047993"},{"key":"e_1_2_17_124_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312323"},{"key":"e_1_2_17_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113113"},{"key":"e_1_2_17_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01263-4"},{"key":"e_1_2_17_127_1","doi-asserted-by":"publisher","DOI":"10.52667\/2712-9179-2024-4-2-11"},{"key":"e_1_2_17_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2023.2292461"},{"key":"e_1_2_17_129_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180584"},{"key":"e_1_2_17_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.03.024"},{"key":"e_1_2_17_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.10.012"},{"issue":"2","key":"e_1_2_17_132_1","first-page":"135","article-title":"GLP\u20101\/GIP\/Gcg Receptor Triagonist Improves the Cognitive Behaviors in Triple\u2010Transgenic Mice of Alzheimer's Disease","volume":"69","author":"Jiao J. J.","year":"2017","journal-title":"Sheng li Xue Bao:[Acta physiologica Sinica]"},{"issue":"1","key":"e_1_2_17_133_1","article-title":"Novel Combination of a Long\u2010Acting GLP\u20101\/GIP\/glucagon Triple Agonist (HM15211) and Once\u2010Weekly Basal Insulin (HM12460a) Offers Improved Glucose Lowering and Weight Loss in a Diabetic Animal Model","volume":"67","author":"Kim J. K.","year":"2018","journal-title":"Diabetes"},{"key":"e_1_2_17_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108042"},{"key":"e_1_2_17_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3761"},{"key":"e_1_2_17_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101533"},{"key":"e_1_2_17_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30013-X"},{"key":"e_1_2_17_138_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0898"},{"key":"e_1_2_17_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13162"},{"key":"e_1_2_17_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114187"},{"key":"e_1_2_17_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.685314"},{"key":"e_1_2_17_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117824"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:11:29Z","timestamp":1764479489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":141,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/hsr2.71065"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71065","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71065"}}