{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:15:44Z","timestamp":1764479744493,"version":"3.46.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The appendix plays an important role to the human intestinal microbiota and immunity. Thus, appendectomy may alter immune function and intestinal biofilm. Allergic rhinitis is a common disease which is due to imbalance of TH2\/TH1 cells and cytokine. The aim of this study was to evaluate the risk of allergic rhinitis after appendectomy in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data source was the National Health Insurance Research Database (NHIRD), which is a large, population\u2010based database in Taiwan. We collected 4013 patients who had undergone appendectomy (case group) between January 1, 2000 and December 31, 2018 and matched them with 16,052 patients who had not undergone appendectomy (control group) by sex and age using proportional propensity score (PSM) at a ratio of 1:4 after excluding patients with a diagnosis of allergic rhinitis in the year prior to appendectomy. In addition, Poisson regression and subgroup analyses were used to investigate the relative risk of the development of allergic rhinitis after appendectomy in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The relative risk of subsequent allergic rhinitis in patients who had undergone appendectomy was found to be higher (RR\u2009=\u20091.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than in patients who had never undergone appendectomy. Subgroup analysis showed the risk of allergic rhinitis after appendectomy was significantly higher in patients aged 6\u201311 years and 12\u201318 years, and for both genders, living place, and lower income groups. When stratified by follow\u2010up duration, the risk of developing allergic rhinitis within 5 years of follow\u2010up was also significantly higher in the exposed group than in the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Appendectomy was correlated with a 1.24\u2010fold increased risk of developing allergic rhinitis in children, especially within 5 years of follow\u2010up. Therefore, we suggest that the indication of appendectomy should be carefully evaluated to decide the best way to treat acute appendicitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71073","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T11:19:51Z","timestamp":1752837591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Allergic Rhinitis and Children With Appendectomy\u2014A Nationwide Population\u2010Based Retrospective Cohort Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9855-7151","authenticated-orcid":false,"given":"Wen\u2010Chun","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Division of Otolaryngology Head and Neck Surgery Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Che","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University Taichung Taiwan"},{"name":"Division of Pediatric Gastroenterology, Children's Medical Center Taichung Veterans General Hospital Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hsun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Cheng\u2010Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Allergy, Immunology and Rheumatology Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"256","article-title":"The Vermiform Appendix: Not a Useless Organ","volume":"14","author":"Zahid A.","year":"2004","journal-title":"Journal of the College of Physicians and Surgeons\u2010\u2010Pakistan"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2020.422"},{"key":"e_1_2_11_4_1","first-page":"31","volume-title":"The Immunological Functions of the Appendix: An Example of Redundancy?","author":"Girard\u2010Madoux M. 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