{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:07:36Z","timestamp":1765512456009,"version":"3.48.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The concentration of cortisol varies during the day and is related to high\u2010stress situations that could lead to the development of mental disorders such as depression. We aimed to determine the level of cortisol and the presence of depression in health workers in the clinical pathology service of a specialized hospital during 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational study conducted in personnel of the clinical pathology service through blood sampling at two time points during the day: in the morning at the beginning of their workday and in the afternoon at the end of it. Moreover, the Zung Depression Scale was also administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010one professionals aged 21\u201367 participated, with an average age of 42\u2009\u00b1\u200910.3 years. Of them, 50.6% were women, mostly medical technologists (59.3%), and the most frequent length of service was 1\u201310 years (43.2%). The serum cortisol concentration in the morning had an average of 10.6\u2009\u00b1\u20094.9\u2009\u03bcg\/dL, and in the afternoon it was 8.4\u2009\u00b1\u20095.9\u2009\u03bcg\/dL, finding differences between both measurements (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The majority of participants (87.7% morning cortisol, 77.7% afternoon cortisol) did not present depression during both measurements. Only 3.7% of workers with cortisol concentrations outside the normal range during the morning (2.5% with low concentration, 1.2% with high concentration) had mild depression, and during the afternoon measurement, 6.2% with high cortisol concentrations had mild depression. We found no correlation between morning (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.580) and afternoon (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.074) cortisol concentrations and depressive symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cortisol levels vary between morning and afternoon in clinical pathology personnel; however, they are not related to the presence of depression. Despite being isolated from human contact, they seem to feel safe in their environment due to the extensive security measures established with the arrival of the COVID\u201019 pandemic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71125","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:44:11Z","timestamp":1761111851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cortisol Concentration Is Reduced During the Workday but Is not Associated With Depressive Symptoms in Healthcare Workers During the COVID\u201019 Outbreak"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-4940","authenticated-orcid":false,"given":"Jeel","family":"Moya\u2010Salazar","sequence":"first","affiliation":[{"name":"Faculty of medicine Universidad Se\u00f1or de Sip\u00e1n Chiclayo Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Bermudo\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Nacional Edgardo Rebagliati Martins Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-7496","authenticated-orcid":false,"given":"Eliane A.","family":"Goicochea\u2010Palomino","sequence":"additional","affiliation":[{"name":"School of Medical Technologist, Faculties of Health Science Universidad Tecnol\u00f3gica del Per\u00fa Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-6253","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Moya\u2010Salazar","sequence":"additional","affiliation":[{"name":"Infectious Unit, Nesh Hubbs Lima Peru"},{"name":"Faculty of Medicine Universidad Norbert Wiener Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-684X","authenticated-orcid":false,"given":"V\u00edctor","family":"Rojas\u2010Zumaran","sequence":"additional","affiliation":[{"name":"Infectious Unit, Nesh Hubbs Lima Peru"},{"name":"Department of Pathology Hospital Nacional Docente Madre Ni\u00f1o San Bartolom\u00e9 Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-9349","authenticated-orcid":false,"given":"Hans","family":"Contreras\u2010Pulache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universidad Norbert Wiener Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"423","article-title":"Systematic Rewiew of Burnout Risk Factors Among European Healthcare Professionals","volume":"16","author":"Bria M.","year":"2012","journal-title":"Cognition, Brain, Behavior: An Interdisciplinary Journal"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12960-021-00628-6"},{"key":"e_1_2_11_4_1","unstructured":"World Health Organization. \u201cDepressive Disorder (Depression) \u201d (2023) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2022.104328"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmclc.2019.10.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/271"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12860"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312118773953"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2015.58"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3417"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105213"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1348-9585.12189"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-022-03764-y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1238569"},{"key":"e_1_2_11_16_1","first-page":"235","article-title":"Communication for Behavior Change of Health Strategies of the Peruvian Government Against COVID\u201019","volume":"145","author":"Macassi Lavander S.","year":"2020","journal-title":"Chasqui: Revista Latinoamericana de Comunicaci\u00f3n"},{"issue":"4","key":"e_1_2_11_17_1","article-title":"Socio\u2010Occupational Factors Associated With Psychological Distress in Healthcare Workers During the COVID\u201019 Pandemic","volume":"51","author":"Mamani\u2010Benito O.","year":"2022","journal-title":"Revista Cubana de Medicina Militar"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.31744\/einstein_journal\/2022AO6707"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.29333\/ejgm\/12140"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4067\/s0717-92272022000300262"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.12961\/aprl.2022.25.03.04"},{"volume-title":"Hospital San Bartolom\u00e9 celebr\u00f3 su 372\u00b0 aniversario institucional al servicio de la comunidad","year":"2018","author":"Ministerio de Salud (MINSA)","key":"e_1_2_11_22_1"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.2379838.v6"},{"key":"e_1_2_11_24_1","unstructured":"Ministerio de Salud (MINSA).Coronavirus: per\u00edodos de aislamiento y descanso medico.2024[Internet] https:\/\/www.gob.pe\/20437-coronavirus-periodos-de-aislamiento-y-descanso-medico."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"},{"issue":"99","key":"e_1_2_11_26_1","first-page":"868","article-title":"Evaluaci\u00f3n estad\u00edstica y adaptaci\u00f3n castellana de la escala autoaplicada para la depresi\u00f3n (S.D.S.) de Zung","volume":"24","author":"Conde V.","year":"1969","journal-title":"Revista de psicolog\u00eda general y aplicada: Revista de la Federaci\u00f3n Espa\u00f1ola de Asociaciones de Psicolog\u00eda"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045413"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcp.2021.11.005"},{"volume-title":"Caracter\u00edsticas de depresi\u00f3n con la aplicaci\u00f3n del phq\u20109 en los cuidadores de pacientes internados en el departamento de pediatr\u00eda del Hospital San Jose durante el periodo de Enero a Febrero del 2019. [Tesis]","year":"2019","author":"Maquin Herrera K. J.","key":"e_1_2_11_29_1"},{"volume-title":"Ansiedad y depresi\u00f3n en relaci\u00f3n a satisfacci\u00f3n laboral en internos de medicina del Hospital Militar Central del Per\u00fa, enero del a\u00f1o 2019. [Tesis]","year":"2019","author":"Zegarra de la Sota Y. S.","key":"e_1_2_11_30_1"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2004-132"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105645"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0020764020950772"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2020.07.022"},{"key":"e_1_2_11_36_1","first-page":"1","article-title":"La COVID\u201019 en el Per\u00fa: una peque\u00f1a tecnocracia enfrent\u00e1ndose a las consecuencias de la desigualdad","volume":"26","author":"Delgado Pugley D.","year":"2020","journal-title":"Fundaci\u00f3n Carolina"},{"key":"e_1_2_11_37_1","article-title":"Comentarios sobre los problemas de salud mental del personal hospitalario andino durante la pandemia de COVID\u201019","volume":"42","author":"Moya\u2010Salazar J.","year":"2023","journal-title":"Rev Cub Inv Biomed"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhqr.2023.03.001"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.29333\/ejgm\/14160"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1136328"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.22354\/in.v25i4.957"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:04:39Z","timestamp":1765512279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/hsr2.71125"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71125","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"type":"print","value":"2398-8835"},{"type":"electronic","value":"2398-8835"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71125"}}