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This narrative review aims to provide an overview of the existing data regarding the IL\u201023 rs2066808, IL\u201023R rs2201841, IL\u201017RA rs4819554, and IL\u201017A rs2275913 polymorphisms and their link to psoriasis and cardiovascular diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Web of Science, Scopus, and \u201cSNPedia\u201d searches were conducted to identify the relevant studies between 2007 and 2025 that investigated the association between psoriasis, cardiovascular diseases, and the IL\u201023 rs2066808, IL\u201023R rs2201841, IL\u201017RA rs4819554, and IL17A rs2275913 polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The existing data are conflicting. The polymorphisms could be implicated in psoriasis onset, disease susceptibility, and treatment response. Some of them are also linked to coronary artery disease. Contradictory data could result from the heterogeneity of the population included in the studies and the laboratory techniques used for polymorphism determination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The interplay between IL\u201017, IL\u201023, and genetic polymorphisms illustrates a complex landscape in psoriasis and its associated comorbidities. More standardized case\u2010control studies are needed to confirm this hypothesis. Moreover, extensive studies in diverse populations would be important to clarify these relationships and the potential implications for treatment and management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.71128","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T10:06:06Z","timestamp":1755079566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Common Genetic Background for Psoriasis and Cardiovascular Diseases: A Narrative Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-8088","authenticated-orcid":false,"given":"Andrada\u2010Luciana","family":"Lazar","sequence":"first","affiliation":[{"name":"Internal Medicine Department 4th Medical Clinic \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"},{"name":"Dermatology Department Integrated Ambulatory \u2010 Infectious Diseases Clinical Hospital Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleopatra","family":"Romana Vulturar","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela\u2010Viviana","family":"Sitar\u2010T\u0103ut","sequence":"additional","affiliation":[{"name":"Internal Medicine Department 4th Medical Clinic \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Suharoschi","sequence":"additional","affiliation":[{"name":"Department of Food Science University of Agricultural Science and Veterinary Medicine Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Hilda","family":"Or\u0103\u0219an","sequence":"additional","affiliation":[{"name":"Internal Medicine Department 4th Medical Clinic \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina Ancu\u021ba","family":"Chi\u0219","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Fodor","sequence":"additional","affiliation":[{"name":"Clinical Center of Diabetes, Nutrition, and Metabolic Diseases \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Br\u00eendu\u0219a","family":"Tiperciuc","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezar","family":"Login","sequence":"additional","affiliation":[{"name":"Department of Physiology \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Cozma","sequence":"additional","affiliation":[{"name":"Internal Medicine Department 4th Medical Clinic \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.743180"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00579"},{"key":"e_1_2_13_4_1","unstructured":"P. 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