{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:29:28Z","timestamp":1784698168723,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>People with cystic fibrosis (pwCF) often have vitamin D deficiency and require vitamin D supplementation. The primary objective of this study was to evaluate the impact of ultrahigh dose cholecalciferol (\u201cstoss dosing\u201d) in pwCF with variable adherence to maintenance cholecalciferol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of pwCF who received initial stoss dose per protocol between January 2017 and November 2021 at University of Iowa Health Care adult and pediatric CF centers. Serum 25(OH)D concentrations were extracted from the EMR. The increase in serum 25(OH)D concentration associated with receiving stoss doses was evaluated using a longitudinal linear mixed effects regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight patients were included in the final analysis. The mean baseline 25(OH)D concentration before stoss therapy was 20.1\u2009ng\/mL (standard deviation [SD]\u2009=\u20095.9). The mean serum 25(OH)D concentration following stoss therapy increased to 27.9\u2009ng\/mL (SD\u2009=\u20097.5) and was measured on average 116 days after stoss administration. For patients with self\u2010reported non\u2010adherence to vitamin regimens, 16 out of 20 (80%) achieved a serum 25(OH)D concentration of at least 30\u2009ng\/mL after stoss therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that stoss dosing was associated with increased serum 25(OH)D concentrations. This benefit also existed for individuals with self\u2010reported non\u2010adherence to maintenance cholecalciferol regimens with most patients reaching concentration goals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.71142","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:30:47Z","timestamp":1754382647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improvements in Serum 25(OH)D Following Stoss Dosing in People With Cystic Fibrosis and Variable Adherence to Maintenance Regimens: A Retrospective Chart Review"],"prefix":"10.1002","volume":"8","author":[{"given":"Katelyn","family":"Gordon","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Care University of Iowa Hospitals and Clinics Iowa City Iowa USA"},{"name":"Pharmacy Department Eskenazi Health Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole G.","family":"Chapman","sequence":"additional","affiliation":[{"name":"University of Iowa College of Pharmacy Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole M.","family":"Harklau","sequence":"additional","affiliation":[{"name":"Food and Nutrition Services University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie Larson","family":"Ode","sequence":"additional","affiliation":[{"name":"Pedatric Endocrinology University of Iowa Stead Family Children's Hospital Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6620-1727","authenticated-orcid":false,"given":"Brittany A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2023.106332"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3050"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdae007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102380"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.163789"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142997"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003999"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.08.030"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.08.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2307"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.20332"},{"key":"e_1_2_11_15_1","unstructured":"RStan: the R interface to Stan. 2024 Stan Development Team."},{"key":"e_1_2_11_16_1","unstructured":"The R Project for Statistical Computing. R Foundation for Statistical Computing. Version 4.4.0."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25781"},{"issue":"2","key":"e_1_2_11_18_1","article-title":"Nutritional Status and Circulating Levels of Fat\u2010Soluble Vitamins in Cystic Fibrosis Patients: A Cohort Study and Evaluation of the Effect of CFTR Modulators","volume":"10","author":"Francalanci M.","year":"2023","journal-title":"Children (Basel, Switzerland)"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00471.x"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:43:57Z","timestamp":1757911437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/hsr2.71142"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71142","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71142"}}