{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:46:43Z","timestamp":1776170803735,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Spontaneous abortion (SA) may be affected by several variables including genetics and lifestyle factors. A recent study discovered that variations in the FTO gene have been associated to both SA and dietary intake. The objective of the study is to examine the association between vitamin E and abortion in individuals with different FTO genotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2010control study was conducted on 539 adult women including 192 women between 20 and 40 years with a history of SA and 347 women without a history of abortion in Tehran, Iran. The blood sample was collected from all participants to evaluate the FTO genotype for rs9939609 polymorphism. A validated Food Frequency Questionnaire was used to assess the intake of vitamin E.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients with SA had a lower intake of vitamin E compared to the control group in carriers of the AA genotype of the FTO gene (15.06\u2009\u00b1\u20097.77 vs. 18.04\u2009\u00b1\u200912.8\u2009mg\/day,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). SA was inversely associated with dietary intake of vitamin E (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.232,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and alpha\u2010tocopherol (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.287,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) only among the cases with AA and AT genotypes of the FTO gene. Adjustments for age, BMI, physical activity, smoking, alcohol drinking, and calorie intake did not change the results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study presents the first evidence indicating a significant negative association between SA and dietary intake of vitamin E, specifically among those who have the A allele of the FTO rs9939609 polymorphism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71147","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:57:53Z","timestamp":1764309473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Link Between Spontaneous Abortion and Vitamin E may be Influenced by the Fat Mass and Obesity\u2010Associated Gene, a Case\u2010Control Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Zahra","family":"Saeedirad","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Mousavi Mele","sequence":"additional","affiliation":[{"name":"Department of Nutrition Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Shamsi\u2010Goushki","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Khodarahmi","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Mother and Child Research Center Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoomeh Alsadat","family":"Mirshafaei","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Sciences Tonekabon Branch, Islamic Azad University Tonekabon Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefeh","family":"Tahavorgar","sequence":"additional","affiliation":[{"name":"School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheyda","family":"Nami","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Iran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyyed Ali","family":"Namakian Yazdi","sequence":"additional","affiliation":[{"name":"Health Sciences in Nutrition, Medical Sciences and Technologies Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloufar Pourmalek","family":"Lahiji","sequence":"additional","affiliation":[{"name":"Faculty of Sciences Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijeh Abbasi","family":"Mobarakeh","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Khoshdooz","sequence":"additional","affiliation":[{"name":"Department of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-7478","authenticated-orcid":false,"given":"Saeid","family":"Doaei","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Reproductive Health Research Center, Department of Obstetrics &amp; Gynecology, Al\u2010Zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Ajami","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Gholamalizadeh","sequence":"additional","affiliation":[{"name":"Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat Barcelona Spain"},{"name":"National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.07.514"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2025.v115i1.1987"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4871494"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1620-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.308.5.516"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-136"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2796-0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37515"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12640"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.74"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1290"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.04.021"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.6.1649"},{"issue":"2","key":"e_1_2_12_15_1","first-page":"362","article-title":"Predictors of Miscarriage in the West of Iran: A Case\u2010Control Study","volume":"6","author":"Mosayebi\u2010Molasaraie M.","year":"2023","journal-title":"Journal of Iranian Medical Council"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2024.55"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12593"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-49"},{"issue":"5","key":"e_1_2_12_19_1","first-page":"334","article-title":"Free Radicals and Antioxidant Systems in Health and Disease","volume":"43","author":"Sinclair A. J.","year":"1990","journal-title":"British Journal of Hospital Medicine"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90017-L"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0844(1998120)16:4<227::AID-CBF787>3.0.CO;2-M"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000293145"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1428648"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v12i2.12"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp025"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00255-7"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/841749"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.1003S"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112257"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S117207"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141634"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060713-035513"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.62"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.71147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:50:01Z","timestamp":1776167401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/hsr2.71147"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71147","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"2024-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71147"}}