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This umbrella review aimed to systematically search, critically appraise, summarize, and synthesize the current systematic reviews (SRs) on delivering VR interventions to rehabilitate patients with chronic primary MSKP and disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data were obtained from five databases. Only SRs were included. This umbrella review utilized the AMSTAR\u20102 to assess the methodological quality of the included SRs and the GRADE to assess the certainty in the body of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven SRs were included. The overall confidence in the SRs ranged from low to critically low, whereas the certainty in the body of evidence ranged from moderate to very low. Whilst the majority of the SRs suggested that VR, standalone or adjunctive to other interventions, had a significant short\u2010term positive effect on patient\u2010reported outcomes for pain in patients with chronic primary MSKP, results on patient\u2010reported outcomes for disability and kinesiophobia were inconsistent. Adverse events included motion sickness, nausea, and vertigo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the current evidence indicates that VR may hold promise in patients with chronic primary MSKP, the included studies suffered from critical weaknesses that precluded this review from drawing a conclusive conclusion. It remains uncertain which VR interventions, including dosage, mode of delivery, supervision, frequency, duration, level of immersion, VR platform, displayed content, and mechanism of action, are more effective than the others. Future SRs should sub\u2010group VR based on the treatment types. Further rigorously designed studies focusing on immersive VR, standalone or adjunctive to other interventions, with long\u2010term follow\u2010up, are warranted. It is worth repeating the call for an agreed consensus on a clear definition and classification of VR within the healthcare context.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.71163","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T03:55:19Z","timestamp":1755057319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Virtual Reality for Patients With Chronic Musculoskeletal Pain and Disability: An Umbrella Review of Systematic Reviews"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3772-6977","authenticated-orcid":false,"given":"Fahad Salman","family":"Alotibi","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, College of Applied Medical Sciences Taif University Taif City Makkah Province Kingdom of Saudi Arabia"},{"name":"Department of Physiotherapy and Rehabilitation Sciences, School of Medical and Health Sciences 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