{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:09:16Z","timestamp":1784549356545,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The role of anti\u2010M\u00fcllerian hormone (AMH), a potential marker of the hypothalamic\u2013pituitary\u2013ovarian axis, is not well established in adolescent females. Typical epidemiologic studies use secondary sexual characteristics or chronological age as predictors for AMH. Skeletal maturity, an indicator of bone development, however, has not been examined in association with AMH in adolescent females. This study aimed to examine patterns of change in AMH levels in relation to skeletal maturity in healthy adolescents from the Fels Longitudinal Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A longitudinal study was conducted on 88 females (212 observations) between the ages of 8 and 18. AMH levels were analyzed using ELISA from stored frozen serum samples. Skeletal age from hand\u2010wrist radiographs, as well as demographics, anthropometrics, and cardiometabolic risk factors, were included in the analysis. In the stepwise linear mixed\u2010effects regression models, log\u2010transformed AMH (AMH\n                      <jats:sub>log<\/jats:sub>\n                      ) was regressed on relative skeletal age, the skeletal maturity indicator calculated as chronological age minus skeletal age. Chronological age modeled as a cubic function, adiposity measures, and cardiometabolic factors such as fasting glucose were included as covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Skeletal maturity significantly predicted lower AMH\n                      <jats:sub>log<\/jats:sub>\n                      (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.073, SE\u2009=\u20090.032,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Serum glucose levels were significantly associated with decreases in AMH\n                      <jats:sub>log<\/jats:sub>\n                      (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.008, SE\u2009=\u20090.004,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Chronological age was not significantly associated with AMH\n                      <jats:sub>log<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed a negative relationship between AMH and skeletal age relative to chronological age. This study highlights that AMH and skeletal maturity provide correlated information on growth and pubertal status in adolescent females.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71209","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T04:55:07Z","timestamp":1757048107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010M\u00fcllerian Hormone Levels Are Associated With Skeletal Maturity in Adolescent Girls: A Longitudinal Study"],"prefix":"10.1002","volume":"8","author":[{"given":"McKenzie L.","family":"Ford","sequence":"first","affiliation":[{"name":"School of Public Health University of Texas Health Science Center at Houston Brownsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey C.","family":"Choh","sequence":"additional","affiliation":[{"name":"School of Public Health University of Texas Health Science Center at Houston Brownsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"College of Medicine University of Houston Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Lindheim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Boonshoft School of Medicine Wright State University Dayton Ohio USA"},{"name":"Department of Obstetrics &amp; Gynecology University of Central Florida Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Z.","family":"Stanczyk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda K.","family":"McGinnis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan A.","family":"Czerwinski","sequence":"additional","affiliation":[{"name":"School of Health and Rehabilitation Sciences, College of Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-304X","authenticated-orcid":false,"given":"Miryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Public Health University of Texas Health Science Center at Houston Brownsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"issue":"10","key":"e_1_2_10_2_1","first-page":"3836","article-title":"Expression of Anti\u2010Mullerian Hormone During Normal and Pathological Gonadal Development: Association With Differentiation of Sertoli and Granulosa Cells","volume":"84","author":"Rajpert\u2010De Meyts E.","year":"1999","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01622-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13334"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa513"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-016-0497-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pbj.0000000000000199"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"638","article-title":"Female Reproductive Health \u2010 Study of an Egg Donor Population","volume":"27","author":"Oliveira T. 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