{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:23:02Z","timestamp":1771482182934,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Recent publications have highlighted the potential diagnostic value of measuring common femoral vein (CFV) wall thickness in Beh\u00e7et's Disease (BD). The diagnosis of BD remains a clinical challenge. The objective of this study is to evaluate the utility of venous Doppler ultrasound measurement of CFV wall thickness as a diagnostic tool for BD and to differentiate it from healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 96 individuals were included: 48 patients with BD and 48 HCs. CFV wall thickness was measured bilaterally using venous Doppler ultrasound. Comparative statistical analyses were performed between groups, and diagnostic cutoff values were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both right and left whole\u2010wall thickness (WWT) of the CFV were significantly higher in the BD group compared to HCs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A diagnostic cutoff value of \u2265\u20090.668\u2009mm for CFV WWT effectively distinguished BD from HCs, with a sensitivity of 89.6% and specificity of 100%. Among BD patients, those with vascular involvement had notably thicker CFV walls. No significant correlations were observed with ocular, neurological, articular, or gastrointestinal involvement, nor with laboratory markers or most treatment modalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ultrasound assessment of CFV wall thickness is a promising, noninvasive diagnostic tool that may aid in differentiating BD from healthy individuals. Its significant association with vascular involvement further supports its role as a potential marker of disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71296","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:08:17Z","timestamp":1758881297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Common Femoral Vein Wall Thickness as a Diagnostic Marker for Beh\u00e7et's Disease: A Case\u2010Control Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6148-4699","authenticated-orcid":false,"given":"Raghad","family":"Tarcha","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine Damascus University Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muttaz","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology N\u00fcrnberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Ali","family":"Nahas","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Faculty of Medicine, National University Hospital Damascus University Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysoun","family":"Kudsi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Damascus University Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104327"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GH9.0000000000000582"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GH9.0000000000000463"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131227"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GH9.0000000000000457"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200301000-00006"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13010041"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00880-7"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13162705"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109306"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23931"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04470-z"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2018.11.006"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06587-7"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa264"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2021.8423"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7788.59946"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/607921"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0428-6"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213225"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01067"},{"issue":"9","key":"e_1_2_14_23_1","first-page":"1683","article-title":"Effects 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