{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:33:27Z","timestamp":1790145207598,"version":"4.0.1"},"reference-count":141,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>SARS\u2010CoV\u20102 continues to pose global challenges, and current vaccines face limitations (variant escape, waning immunity). This review evaluates immunostimulatory adjuvants and nano\u2010adjuvants to enhance immune responses and optimize SARS\u2010CoV\u20102 vaccine performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative review of preclinical and clinical evidence on alum, emulsions (MF59, AS01\/AS03), Montanide ISA\u201051, delta inulin, TLR agonists (e.g., CpG, TLR3), rOv\u2010ASP\u20101, and nano\/mucosal platforms (liposomes, polymeric or metal nanoparticles, Protollin) for SARS\u2010CoV\u20102 and related coronaviruses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Alum and emulsions increased neutralizing antibodies; Th1\u2010promoting combinations (e.g., CpG with Montanide or with protein antigens) mitigated Th2\u2010biased immunopathology seen with some inactivated vaccines. MF59, AS01\/AS03, and Matrix\u2010type systems enhanced humoral and cellular responses, with early clinical data supporting acceptable safety and robust immunogenicity. Delta inulin (\u00b1CpG) boosted neutralization without lung injury in comparative models. TLR agonists and intranasal Protollin induced systemic IgG and mucosal IgA. Nano\u2010adjuvants improved antigen presentation and enabled dose\u2010sparing while supporting balanced, durable immunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Immunostimulatory and nano\u2010adjuvants substantially strengthen SARS\u2010CoV\u20102 vaccine immunogenicity, support antigen\u2010sparing, and favor balanced (often Th1\u2010biased) protection. Prudent adjuvant selection and integration of conventional and nanotechnology\u2010derived platforms are key to achieving safe, durable, and broadly protective COVID\u201019 vaccines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71405","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T09:04:48Z","timestamp":1763370288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Immunostimulatory Adjuvants and Nano\u2010Adjuvants in Current SARS\u2010CoV\u20102 Vaccines: A Comprehensive Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-1370","authenticated-orcid":false,"given":"Peyman Kheirandish","family":"Zarandi","sequence":"first","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"},{"name":"Cancer Biology Signaling Pathway Interest Group (CBSPIG) Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Zinatizadeh","sequence":"additional","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"},{"name":"Cancer Biology Signaling Pathway Interest Group (CBSPIG) Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-5804","authenticated-orcid":false,"given":"Mohsen","family":"Ghiasi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Rajaie Cardiovascular Institute Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-4344","authenticated-orcid":false,"given":"Mohammad Rezaei Zadeh","family":"Rukerd","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology, Cell Science Research Center Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Mirkamali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-5637","authenticated-orcid":false,"given":"Ehsan","family":"Shokri","sequence":"additional","affiliation":[{"name":"Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research Education and Extension Organization (AREEO) Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30185-9"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CP04389C"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2024.03.015"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2023.059"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116800"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111352"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.02.001"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1719902"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2438-7_1"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12328"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0334-7"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007236"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00127-20"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104742"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306446101"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2014.11.021"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00642-4"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.03.025"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1167603"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1107.050219"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112527"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.06.002"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.01.111"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10091555"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2005630"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008548"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00169-X"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.1151-1159.2001"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.424"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711795933740"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071087"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11061045"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh143"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454904323145272"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.06.038"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-018-0009-2"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0056-7"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1177688"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06048-11"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035421"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6337"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0321-6"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030525"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02980-14"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.01.059"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2012.0076"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.27464"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.06.111"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.11.092"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.04.016"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8475"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.08.031"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.6.5.699"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804019-5.00013-X"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.11.23"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903181106"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2018.1495301"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00339-16"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1108.041003"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1021527"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01093"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1296994"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.10.005"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12088"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00200-0"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2016.1213632"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-017-0027-3"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.01.042"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60721-8"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.09.073"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq160"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.035"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2010.0028"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1071455"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.1.1.111"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.949-957.2004"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011995"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4619"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9632-5"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13070768"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.01.058"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.164"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-0556-3-7"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01048-13"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.019190-0"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.09.030"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwq201"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.021"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00978.x"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2014.920236"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00669-13"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00983-14"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01410-12"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2007.0079"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-011-3183-z"},{"key":"e_1_2_18_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.12.019"},{"key":"e_1_2_18_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.06.100"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.06.084"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.11.064"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800531"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00685.x"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037019"},{"key":"e_1_2_18_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.07.028"},{"key":"e_1_2_18_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-9"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.098"},{"key":"e_1_2_18_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.03.052"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB01131D"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-chembioeng-060718-030203"},{"key":"e_1_2_18_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102316"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201962"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn404211j"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.15.1200"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.04.014"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.03.008"},{"issue":"4","key":"e_1_2_18_125_1","first-page":"125","article-title":"Nanoparticles in Vaccine Development","volume":"1","author":"Hajizade A.","year":"2014","journal-title":"Journal of Applied Biotechnology Reports"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2020-0117"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12754"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1932"},{"key":"e_1_2_18_129_1","article-title":"An Evidence Based Perspective on mRNA\u2010SARS\u2010CoV\u20102 Vaccine Development","volume":"26","author":"Wang F.","year":"2020","journal-title":"Medical Science Monitor"},{"key":"e_1_2_18_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00268-7"},{"key":"e_1_2_18_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.03.035"},{"key":"e_1_2_18_132_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201194"},{"key":"e_1_2_18_133_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.6.2382-2386.1995"},{"key":"e_1_2_18_134_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4545-4553.2001"},{"key":"e_1_2_18_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163089"},{"key":"e_1_2_18_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.06.017"},{"key":"e_1_2_18_137_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_18_138_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_18_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32661-1"},{"key":"e_1_2_18_140_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101544"},{"key":"e_1_2_18_141_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107659"},{"key":"e_1_2_18_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.243"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.71405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:12:58Z","timestamp":1787245978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":141,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/hsr2.71405"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71405","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71405"}}