{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:29:36Z","timestamp":1787246976918,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>During the coronavirus disease 2019 (COVID\u201019) pandemic, acute pancreatitis (AP) in patients with COVID\u201019 has attracted considerable attention. While many reports have described \u201cconcurrent COVID\u201019 and AP\u201d without excluding established etiologies, the concept of \u201cCOVID\u201019\u2013induced AP\u201d remains less clearly defined. This study aimed to investigate the associations between initial clinical presentations and outcomes in COVID\u201019\u2013induced AP, offering real\u2010world evidence to identify predictors of short\u2010term prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a review\u2010based synthesis for human studies, with literature search (October 2019\u2013March 2022) using PubMed dual strategies, \u201cMedical Subject Headings (MeSH)\u201d and \u201ctitle\/abstract.\u201d COVID\u201019\u2013induced AP was defined by the exclusion of other established etiologies for pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 111 patients (median age 39 years) with 11 deaths. Gastrointestinal symptoms preceded admission in 30.6% of cases, while respiratory symptoms preceded admission in 52.3%. Pancreatitis symptoms before admission were associated with younger age, less lymphocyte counts, lower neutrophil\u2010to\u2010lymphocyte ratio, and higher radiologic severity (Balthazar score). Initial white blood cell (WBC) count \u2265\u200914,000\/\u00b5L and pancreatic necrosis correlated with surgical intervention. Kaplan\u2013Meier analysis demonstrated that overall survival was not influenced by the sequence of gastrointestinal and respiratory symptom onset (concurrent vs. successive;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.543) or by whether pancreatitis symptoms developed before or after hospital admission (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.228). Multivariate Cox regression identified elevated WBC count (hazard ratio [HR]: 1.013; 95% confidence interval [CI]: 1.000\u20131.025;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042), AST\u2010to\u2010ALT ratio \u2265\u20092 (HR: 11.052; 95% CI: 1.441\u201384.770;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), and surgical intervention (HR: 6.604; 95% CI: 1.581\u201327.593;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) as independent mortality predictors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Unlike \u201cconcurrent COVID\u201019 and AP (without excluding established AP etiologies),\u201d \u201cCOVID\u201019\u2013induced AP\u201d showed no survival disparity by symptom chronology. Mortality was linked to leukocytosis, AST\u2010to\u2010ALT ratio, and surgical intervention. Standardized terminology distinguishing \u201cCOVID\u201019\u2013induced AP\u201d from \u201cconcurrent COVID\u201019 and AP\u201d is essential to ensure comparability of global clinical data and reduce interpretive bias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71417","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:34:11Z","timestamp":1761658451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["COVID\u201019\u2013Induced Acute Pancreatitis: Clinical Profiles, Outcomes, and Prognostic Indicators From a Global Review\u2010Based Synthesis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-0891","authenticated-orcid":false,"given":"Yu\u2010Jhou","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Chang Gung Memorial Hospital, Linkou Chang Gung Medical Foundation Taoyuan City Taiwan (R.O.C.)"},{"name":"College of Medicine Chang Gung University Taoyuan City Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hsing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Chang Gung Memorial Hospital, Linkou Chang Gung Medical Foundation Taoyuan City Taiwan (R.O.C.)"},{"name":"College of Medicine Chang Gung University Taoyuan City Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0984-8385","authenticated-orcid":false,"given":"Chen\u2010June","family":"Seak","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University Taoyuan City Taiwan (R.O.C.)"},{"name":"Department of Emergency Medicine New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation) New Taipei City Taiwan (R.O.C.)"},{"name":"Department of Emergency Medicine Chang Gung Memorial Hospital, Linkou Chang Gung Medical Foundation Taoyuan City Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Mu","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Chang Gung Memorial Hospital, Linkou Chang Gung Medical Foundation Taoyuan City Taiwan (R.O.C.)"},{"name":"College of Medicine Chang Gung University Taoyuan City Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University Taoyuan City Taiwan (R.O.C.)"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation) New Taipei City Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen\u2010Yung","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Chang Gung Memorial Hospital, Linkou Chang Gung Medical Foundation Taoyuan City Taiwan (R.O.C.)"},{"name":"College of Medicine Chang Gung University Taoyuan City Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-738X","authenticated-orcid":false,"given":"Hao\u2010Tsai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Chang Gung Memorial Hospital, Linkou Chang Gung Medical Foundation Taoyuan City Taiwan (R.O.C.)"},{"name":"College of Medicine Chang Gung University Taoyuan City Taiwan (R.O.C.)"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation) New Taipei City Taiwan (R.O.C.)"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Chang Gung University Taoyuan City Taiwan 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