{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:29:58Z","timestamp":1787246998151,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to characterize the 5\u2010day trajectory of nutritional and metabolic profiles and identify influencing factors in adults receiving VA\u2010ECMO support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 46 patients with cardiogenic shock receiving VA\u2010ECMO (2022\u20132024; median age 50 [IQR: 41.0\u201363.3]) were prospectively enrolled. Demographic, clinical, nutritional, and metabolic biomarkers were serially collected over 5 days. Multivariate analysis was employed to evaluate longitudinal trends and determinants of change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant dynamic changes were observed in nutritional and metabolic parameters, including serum albumin, neutrophil count, prognostic nutrition index (PNI), triceps skinfold thickness, and mid\u2010upper arm circumference. A marked decline in albumin occurred within the first 48\u2009h (mean differences: \u20135.663,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035; \u20135.728,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Age and hyperlipidemia were independent factors affecting albumin levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032, respectively). Progressive reductions in skinfold thickness and arm circumference were noted from day 2 to day 5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ECMO support is associated with early changes in nutritional status. Rapid albumin decline within 48\u2009h and later anthropometric reductions suggest a need for prompt nutritional monitoring and individualized intervention, though further validation is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Clinical Practice<\/jats:title>\n                    <jats:p>These findings highlight the critical importance of integrated nutritional and metabolic management initiated early during VA\u2010ECMO support to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71421","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:48:14Z","timestamp":1761662894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Five\u2010Day Trajectory of Nutritional Indicators and Influencing Factors in Adult Patients After VA\u2010ECMO: A Prospective Observational Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-2550","authenticated-orcid":false,"given":"Wenyu","family":"Li","sequence":"first","affiliation":[{"name":"CCU The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"CCU The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Xie","sequence":"additional","affiliation":[{"name":"CCU The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[{"name":"CCU The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianlian","family":"Sun","sequence":"additional","affiliation":[{"name":"CCU The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Yan","sequence":"additional","affiliation":[{"name":"CCU The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Xu","sequence":"additional","affiliation":[{"name":"Nursing Department The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.12.024"},{"key":"e_1_2_10_3_1","unstructured":"Extracorporeal Life Support Organization. ELSO Registry report [R\/OL]. (2020): 2021\u20132025 https:\/\/www.elso.org\/Registry\/Statistics\/InternationalSummary.aspx."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2025.05.021"},{"key":"e_1_2_10_5_1","first-page":"10","article-title":"Cardiac Critical Care Medicine of China International Exchange and Promotion for Medical and Healthcare, Nutrition Support Expert Committee of Chinese Cardiac Critical Care Medicine, Chinese Consensus Guideline for Nutrition Support Therapy in the Perioperative Period of Adult Cardiac Surgery in 2019","volume":"31","year":"2019","journal-title":"Chinese Critical Care Medicine"},{"key":"e_1_2_10_6_1","first-page":"190","article-title":"Advances in Nutritional Support for Patients With Extracorporeal Membrane Oxygenation","volume":"12","author":"Shengnan Y.","year":"2014","journal-title":"Chinese Journal of Extracorporeal Circulation"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.11.017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12383"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10591"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2415-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000001162"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2023.07.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.04.029"},{"key":"e_1_2_10_14_1","first-page":"5","article-title":"Precision Nutrition for Intensive Care Patients","volume":"29","author":"Guizhen X.","year":"2017","journal-title":"Chinese Critical Care Medicine"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004876"},{"issue":"3","key":"e_1_2_10_16_1","first-page":"367","article-title":"Effect of Nutritional Support on Clinical Outcomes in Perioperative Malnourished Patients: A Meta\u2010Analysis","volume":"24","author":"Zhong J. X.","year":"2015","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13137"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004084"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12234"},{"key":"e_1_2_10_20_1","volume-title":"(Translated by Yao Hesheng). 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