{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:46:26Z","timestamp":1776170786887,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Immune thrombocytopenia (ITP) is an autoimmune disorder with increased bleeding risk. Eltrombopag, an oral thrombopoietin receptor agonist, is widely used after corticosteroids or immunoglobulins. Multiple meta\u2010analyses support its efficacy, yet safety concerns persist. We conducted an umbrella review to synthesize evidence on efficacy and safety across age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Scopus, and Web of Science through April 2025 for systematic reviews\/meta\u2010analyses on eltrombopag in ITP. Methodological quality was appraised using AMSTAR 2. Outcomes included platelet response, bleeding, and adverse events. We mapped primary trials across reviews to address overlap and qualitatively summarized findings; no new pooling was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine meta\u2010analyses met inclusion. Across adult\/mixed populations, eltrombopag increased platelet response (e.g., RR\u2009\u2248\u20093.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and reduced bleeding; pediatric effects were directionally similar but less precise with higher heterogeneity. Reported adverse events included hepatobiliary abnormalities and thrombotic events, underscoring the need for monitoring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eltrombopag is effective in raising platelet counts and reducing bleeding in ITP. Benefits appear to increase up to ~50\u2009mg daily and plateau thereafter. Age\u2010related variability and safety considerations support individualized dosing and vigilant follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71429","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:24:59Z","timestamp":1765783499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Umbrella Review of Meta\u2010Analyses on the Efficacy and Safety of Eltrombopag in Immune Thrombocytopenia"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5159-5591","authenticated-orcid":false,"given":"Mahsa","family":"Dabir","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, School of Paramedical Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam Kamrani","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Student Research Committee Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shervin","family":"Manteghi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, School of Paramedical Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Amin","family":"Mansoori","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Nutrition Science, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Karpasand","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Zoghi","sequence":"additional","affiliation":[{"name":"Student Research Committee Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0074-7166","authenticated-orcid":false,"given":"Mehrdad","family":"Payandeh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Kermanshah University of Medical Sciences Kermanshah 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Multi\u2010Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real\u2010Life Experience","volume":"36","author":"\u00c7ekdemir D.","year":"2019","journal-title":"Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32835fac99"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-182848"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1531824"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jmahp13020011"},{"issue":"5","key":"e_1_2_13_31_1","first-page":"240","article-title":"Real\u2010World Experience of Eltrombopag in Immune Thrombocytopenia","volume":"10","author":"Mishra K.","year":"2020","journal-title":"American Journal of Blood 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