{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:29:50Z","timestamp":1787246990642,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection is associated with increased intestinal permeability. It promotes the passage of bacterial endotoxin through the portal vein and reaches the liver, constituting a factor in the aggravation of hepatitis. This study aims to investigate the impact of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      coinfection with HBV\/HCV on the progression of hepatic pathophysiology, specifically the inflammatory system and hematological parameters, with the goal of enhancing the care of patients with hepatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An analytical cross\u2010sectional study was carried out for 6 months in 2023. This study was carried out in people infected with the hepatitis B and\/or C virus who were being monitored at Laquintinie Hospital. After having informed the participants about the objective of the study and obtaining their consent, we collected sociodemographic data and clinicobiological history. Subsequently, the diagnosis of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was made by testing for immunoglobulins G and M using the ELISA method. Then, inflammation was explored through the determination of C\u2010reactive protein (CRP) and the cytokines Interleukin\u20106 and Interleukin\u20108 (IL\u20106, and IL\u20108). Finally, the hemogram was carried out by the flow cytometry method. The data obtained were analyzed using SPSS statistical software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study population consisted of 184 patients with hepatitis, including 113 (61.4%) cases of hepatitis B and 71 (38.6%) cases of hepatitis C. A total of 94 (51.1%) patients were male and 90 (48.9%) female for a mean age of 41.55\u2009\u00b1\u200916.90 years. The frequency of coinfection was 37.5%. The mean CRP was 3.79\u2009\u00b1\u20093.5\u2009mg\/dL and 2.4\u2009\u00b1\u20092.1\u2009mg\/dL in coinfected and non\u2010coinfected patients, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.057). IL\u20106 was significantly associated with coinfection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Furthermore, elevated IL\u20106 was a predictive sign of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection in patients with viral hepatitis B\/C (OR\u2009=\u20092.88 [0.82\u201310.11];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Furthermore, 22 (12.0%) patients presented thrombocytopenia, including 21 (30.4%) in the coinfected group and 1 (0.9%) in the non\u2010coinfected group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Moreover, the reduction in platelets is a predictive factor of\n                      <jats:italic>H.<\/jats:italic>\n                      pylori infection (OR\u2009=\u20092.34[0.11\u20137.6];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results suggest that hepatitis B\/C and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      coinfection is a factor in worsening inflammation and thrombocytopenia in patients. Hence, the a need to prevent\n                      <jats:italic>H. pylori<\/jats:italic>\n                      coinfection and control the progression of the disease in patients with hepatitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71433","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:26:03Z","timestamp":1762500363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Helicobacter pylori<\/i>\n                    Infection Increases Thrombocytopenia and Inflammation in Patients With Hepatitis B and\/or C: An Analytical Study in Cameroon"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-0538","authenticated-orcid":false,"given":"Romaric Tuono De","family":"Manfouo","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences: Universit\u00e9 des Montagnes Bangangt\u00e9 West\u2010Cameroon"},{"name":"Faculty of Medicine and Biomedical Sciences Universit\u00e9 de Yaound\u00e9 1 Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr4637"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90957-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a018040"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0588-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","unstructured":"C.BurucoaandA.Axon \u201cEpidemiology ofHelicobacter pyloriinfection \u201d supplement Helicobacter 22 no. 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