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However, limited research has specifically examined factors influencing quality of life in individuals with venous leg ulcers (VLUs) using disease\u2010specific measures. This study aimed to identify the key determinants of quality of life in individuals with VLUs and to examine the most salient predictors within this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional, correlational study was conducted between 2019 and 2024 at a clinical research center affiliated with a major university medical center in the USA. A total of 93 community\u2010dwelling, middle\u2010aged and older adults with VLUs participated in the study. Disease\u2010specific quality of life was measured using the VEINES\u2010QOL\/Sym questionnaire. A multiple linear regression was used to identify the potential predictors of the VEINES QOL\/Sym.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Several factors emerged as significant predictors of reduced quality of life. Participants who were middle\u2010aged, had comorbid atherosclerosis or heart failure, were current smokers, or reported greater ulcer pain, perceived stress, or venous disease severity were more likely to experience diminished quality of life. Among these, ulcer pain, perceived stress, and current tobacco use were strongest predictors, with ulcer pain identified as the most powerful determinant of both impaired quality of life and increased symptom severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight the complex interaction of physical, psychological, and behavioral factors, underscoring the need for targeted interventions to better manage pain, stress, and tobacco use. Despite the significant psychosocial impact of VLUs, current clinical guidelines do not adequately address these factors, suggesting a need for revisions to improve patient\u2010centered care. Interventions targeting these modifiable factors are warranted to improve outcomes in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71441","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:18:54Z","timestamp":1762845534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors Associated With Quality of Life in Patients With Venous Leg Ulcers in a Community Setting: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-4928","authenticated-orcid":false,"given":"Jodi Christine","family":"McDaniel","sequence":"first","affiliation":[{"name":"College of Nursing The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Nursing Inje University Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina Rose","family":"McGowan","sequence":"additional","affiliation":[{"name":"Clinical Research Center The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alai","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Nursing The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13242"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2021.04.006"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2015.05.002"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12911"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2015.02.016"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/0034-7167-2017-0516"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.13465"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.25270\/WNDS\/2017.10.306310"},{"key":"e_1_2_15_11_1","unstructured":"World Health Organization \u201cWHOQOL: Measuring Qualify of Life \u201d published May 2020 https:\/\/www.who.int\/tools\/whoqol."},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000436"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare2030346"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2022.09.005"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2010.05568.x"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012583.pub2"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.11.071"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-021-00213-x"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13000"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195990"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2022.124709"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00537-1"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198903001-00018"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0080-7"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3970-7"},{"key":"e_1_2_15_26_1","volume-title":"StatPearls","author":"Weir C. 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