{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:29:53Z","timestamp":1787246993692,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Endometriosis is a condition in which tissue similar to the endometrium grows outside the uterus. Angiogenesis plays an important role in endometriosis development. Bioinformatics analysis indicates that miR\u2010410\u20103p is involved in regulating\n                      <jats:italic>VEGF, NUMB<\/jats:italic>\n                      endocytic adaptor protein, and Protocadherin 8 (\n                      <jats:italic>PCDH8<\/jats:italic>\n                      ) expression. Therefore, this study sought to assess miR\u2010410\u20103p,\n                      <jats:italic>VEGFA<\/jats:italic>\n                      ,\n                      <jats:italic>NUMB<\/jats:italic>\n                      , and\n                      <jats:italic>PCDH8<\/jats:italic>\n                      expression in ovarian endometriosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study analyzed 48 ectopic and eutopic tissue samples from individuals with ovarian endometriosis along with 48 controls. The levels of miR\u2010410\u20103p and its corresponding hub genes were analyzed through real\u2010time PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The findings demonstrated a decrease in miR\u2010410\u20103p expression in the ectopic (0.53\u2009\u00b1\u20090.09\u2010fold) compared to both the eutopic and the controls, which was 0.95\u2009\u00b1\u20090.09\u2010fold and 1.007\u2009\u00b1\u20090.12\u2010fold, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). However, no significant difference was observed between the eutopic samples and the control group (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &gt;\u20090.99). The findings also indicated that\n                      <jats:italic>VEGF<\/jats:italic>\n                      expression was elevated in the ectopic (1.38\u2009\u00b1\u20090.26\u2010fold) when in comparison to both eutopic and controls, which was 0.98\u2009\u00b1\u20090.08\u2010fold and 1.002\u2009\u00b1\u20090.12\u2010fold, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, there was no notable difference detected between the eutopic group and the controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.99). The results for\n                      <jats:italic>NUMB<\/jats:italic>\n                      expression levels showed higher expression in ectopic (1.50\u2009\u00b1\u20090.33\u2010fold) in comparison to the eutopic (0.98\u2009\u00b1\u20090.10\u2010fold) and controls (1.004\u2009\u00b1\u20090.14\u2010fold) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). But, no notable difference was observed between the eutopic and control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.99). Moreover,\n                      <jats:italic>PCDH8<\/jats:italic>\n                      expression was decreased in ectopic endometriosis (1.002\u2009\u00b1\u20090.14\u2010fold) compared to both eutopic (1.001\u2009\u00b1\u20090.10\u2010fold and controls (1.002\u2009\u00b1\u20090.14\u2010fold) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Nevertheless, there was no statistically significant difference between the eutopic samples and the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      It is proposed that miR\u2010410\u20103p, along with its target genes\n                      <jats:italic>VEGFA, NUMB, and PCDH8,<\/jats:italic>\n                      may play a role in the ovarian endometriosis development and hold possible therapeutic significance for this disease.\n                    <\/jats:p>\n                  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