{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:29:52Z","timestamp":1787246992312,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The re\u2010emergence of COVID\u201019 in India and South Asia, driven by the Omicron variant (NB. 1.8.1), poses an urgent challenge to global pandemic preparedness amid waning citizen awareness and reduced monitoring. This review aims to examine the variant\u2032s characteristics, assess its public health impact, and evaluate the regional and global responses to this resurgence. Here, we examine the characteristics of the NB.1.8.1 outbreak, the magnitude of its effect on public health, and analyze regional and global responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a comprehensive literature search across important databases to extract information, followed by concentrating on recent insights regarding the dissemination and therapeutic implications of SARS\u2010CoV\u20102 NB.1.8.1 variant from PubMed, Nature, and The Lancet Infectious Diseases, and genomic surveillance tools including GISAID and Nextstrain in detail.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SARS\u2010CoV\u20102 NB.1.8.1 variant showed mutations associated with higher transmissibility and evasion by immunity, which prompt fears among individuals with weakened immune system and poor uptake of the booster vaccine. The phenomenon of the emergence of this variant has resulted in more cases of infections and hospitalizations in South Asia, especially in the densely populated and poorly resourced regions. Although the actual deaths are not high, there is a threat of a faster spread and an overwhelmed health system. The reactive measures put in place by India and other neighboring countries include renewing vaccination campaigns, wearing masks, and genomic surveillance. However, there is still little response at the international level, partly due to the uncertainty of disease severity and low mortality rates by this variant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The article points to the relevance of novel therapeutics, a fast tool of diagnostics, and compliance with preventive measures among the population. Timely global cooperation, active communication, and responsive health\u2010related mechanisms are required to tackle the current wave and avoid further surges in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71453","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:49:49Z","timestamp":1762840189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resurgent COVID\u201019 Wave in India and South Asia: Is the NB.1.8.1 Variant a Renewed Global Health Concern?"],"prefix":"10.1002","volume":"8","author":[{"given":"Abir Hasan","family":"Pranto","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy University of Dhaka Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika Tabassum","family":"Promi","sequence":"additional","affiliation":[{"name":"Microbiology Program, Department of Mathematics and Natural Science BRAC University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salsabil","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-3144","authenticated-orcid":false,"given":"Md. Rabiul","family":"Islam","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"StatPearls","author":"Aleem A.","year":"2025"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03068374.2020.1814078"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdisas.2020.100080"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-021-03794-8"},{"key":"e_1_2_12_6_1","article-title":"COVID\u201019 Risks to Global Food Security","volume":"1","author":"Laborde D.","year":"2020","journal-title":"Public Health in Practice"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1112-0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00154"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.13.06014"},{"key":"e_1_2_12_10_1","unstructured":"Outbreak Info \u201cSARS\u2010CoV\u20102 Data Explorer \u201d 2025 https:\/\/outbreak.info\/epidemiology?location=SouthAsia."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.01.001"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00356-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28214"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00308-1"},{"key":"e_1_2_12_15_1","unstructured":"P. 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S.Saha \u201cCOVID\u201019 Cases Rising With Test Kit Crisis and Low Vaccine Stocks \u201d Prothomalo Published June 9 2025 https:\/\/en.prothomalo.com\/bangladesh\/dxvx0lnh4e?utm."},{"key":"e_1_2_12_16_1","unstructured":"Medpagetoday \u201cHere\u2032s What to Know About NB.1.8.1 the COVID Variant Surging in Asia \u201d2025 https:\/\/www.medpagetoday.com\/infectiousdisease\/covid19\/115806."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-024-02223-y"},{"key":"e_1_2_12_18_1","unstructured":"The Economic Times \u201cNew Covid NB.1.8.1 and LF.7 Subvariants Detected in India as Cases Tick Up in Pockets \u201d Published May 24 2025 https:\/\/economictimes.indiatimes.com\/news\/india\/new-covid-nb-1-8-1-and-lf-7-subvariants-detected-in-india-as-cases-tick-up-in-pockets\/articleshow\/121377974.cms."},{"key":"e_1_2_12_19_1","unstructured":"The Business Standard \u201cWhat We Know About the New Covid\u201019 Variant NB.1.8.1 \u201d Published June 10 2025 https:\/\/www.tbsnews.net\/bangladesh\/health\/what-we-know-about-new-covid-19-variant-nb181-1161426."},{"key":"e_1_2_12_20_1","unstructured":"World Health Organization \u201cTracking SARS\u2010CoV\u20112 Variant NB.1.8.1: Initial Risk Evaluation \u201d May\u202f23 \u202f2025 https:\/\/cdn.who.int\/media\/docs\/default-source\/documents\/epp\/tracking-sars-cov-2\/23052025_nb.1.8.1_ire.pdf."},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2023.11.005"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.06.21.22276724"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.71453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:15:24Z","timestamp":1787246124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/hsr2.71453"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71453","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71453"}}