{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:24:05Z","timestamp":1791440645555,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In low\u2010 and middle\u2010income countries, dolutegravir\u2010based antiretroviral therapy regimens are the preferred first\u2010line treatment for adults, adolescents, and children with human immunodeficiency virus (HIV). Dolutegravir exhibits a higher genetic barrier to resistance, improved tolerability, and reduced potential for drug\u2010drug interactions. However, emerging reports suggest a possible association between dolutegravir usage and hyperglycemia. Therefore, this study aims to investigate the hyperglycemia risk in dolutegravir\u2010based antiretroviral therapy among people living with HIV and tuberculosis (TB) in Zimbabwe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An analytical cross\u2010sectional study was conducted on 162 participants aged 18 and older, recruited from April to July 2024 in Harare, Zimbabwe. Participants were divided into three groups based on their HIV and TB status and dolutegravir dosage. Participants' glycated hemoglobin levels were analyzed to determine the hyperglycaemic risk. A questionnaire was also administered to assess the risk factors associated with hyperglycemia. The R statistical software (version 4.3.2, Vienna, Austria) was used for data analysis. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of\u2009&lt;\u20090.05 was considered to be statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median (interquartile range) ages for these sub\u2010groups were 44 [36\u201356], 44 (29.3\u201354.8), and 45 [35\u201356] years, respectively, and the age range was 20\u201080 years. The group taking 100\u2009mg of dolutegravir had a 40% prevalence of impaired glucose regulation, and a hyperglycemia prevalence of 31%. In the multivariable logistic regression analysis, taking 100\u2009mg of dolutegravir was associated with a 5.17 (95% Confidence Interval: 1.21\u201327.82) fold risk of developing hyperglycemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study findings indicate that the prevalence of hyperglycemia and impaired glucose regulation is high in patients taking dolutegravir\u2010based antiretroviral therapy in Zimbabwe. People living with both HIV and TB taking a double dose of dolutegravir are at a higher risk of hyperglycemia and impaired glucose regulation than those taking lower doses. This emphasizes the necessity for clinical and public health interventions to mitigate this emerging hyperglycaemic risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71480","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:47:33Z","timestamp":1762760853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and Correlates of Hyperglycemia Among People Living With HIV and TB on Dolutegravir\u2010Based Antiretroviral Therapy in Zimbabwe: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Tafadzwa","family":"Zireva","sequence":"first","affiliation":[{"name":"Chemical Pathology Unit, Department of Laboratory Diagnostic and Investigative Sciences, Faculty of Medicine and Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuthbert","family":"Musarurwa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Sciences, School of Health Sciences, College of Medicine and Health Sciences University of Rwanda Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Mazhandu","sequence":"additional","affiliation":[{"name":"Chemical Pathology Unit, Department of Laboratory Diagnostic and Investigative Sciences, Faculty of Medicine and Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Nherera","sequence":"additional","affiliation":[{"name":"Chemical Pathology Unit, Department of Laboratory Diagnostic and Investigative Sciences, Faculty of Medicine and Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shungu","family":"Munyati","sequence":"additional","affiliation":[{"name":"Biomedical Research and Training Institute Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justen","family":"Manasa","sequence":"additional","affiliation":[{"name":"Biomedical Research and Training Institute Harare Zimbabwe"},{"name":"Oncology Unit, Department of Internal Medicine, Faculty of Medicine and Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai Tavonga","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medical Laboratory Sciences Unit, Department of Laboratory Diagnostic and Investigative Sciences, Faculty of Medicine and Health Sciences University of Zimbabwe Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8720-0835","authenticated-orcid":false,"given":"Donald","family":"Vhanda","sequence":"additional","affiliation":[{"name":"Chemical Pathology Unit, Department of Laboratory Diagnostic and Investigative Sciences, Faculty of Medicine and Health Sciences University of Zimbabwe Harare Zimbabwe"},{"name":"Biomedical Research and Training Institute Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz256"},{"key":"e_1_2_12_3_1","unstructured":"Pan American Health Organisation World Health Organisation. 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