{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:29:43Z","timestamp":1787246983931,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina affecting preterm infants that potentially leads to blindness. Omega\u20103 long\u2010chain polyunsaturated fatty acids (LCPUFA) have anti\u2010inflammatory and antiangiogenic effects, thereby reducing pathological neovascularization and preventing the incidence of ROP. This study was done to evaluate the effect of available omega\u20103 LCPUFA supplementation for the prevention of ROP among Bangladeshi infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pilot study was conducted in the Neonatology Department of a tertiary care hospital in Bangladesh from November 2022 to March 2024 among preterm neonates &lt;\u200934 weeks of gestation with birth weight &lt;\u20091800\u2009g. Initially, 76 preterm neonates were enrolled in this study. Among them, 71 preterm neonates were randomly allocated to the intervention group and the control group. The intervention group received a cap. omega\u20103 LCPUFA enterally (40\u2009mg\/kg\/day). It was added to their enteral feeds within 48\u2009h of the first enteral feed and continued from the starting point to 4 weeks. The control group received no supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of ROP was almost similar between the omega\u20103 LCPUFA group and the control group (37.1% in the intervention group vs. 41.6% in the control group,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.69). However, severe ROP incidence was significantly reduced in the omega\u20103 group. Three patients developed severe ROP in the omega\u20103 LCPUFA group, in contrast to nine patients in the control group (23.1% vs. 60%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049). On logistic regression analysis, while considering risk factors for ROP, omega\u20103 LCPUFA supplementation was not found to have a significant association with the incidence of ROP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Omega\u20103 LCPUFA supplementation does not reduce the overall incidence of ROP; however, it may lower the risk of severe ROP. This reduction in severe ROP cases may help decrease the need for invasive treatments and improve long\u2010term visual outcomes in preterm infants. Nonetheless, the study lacks sufficient statistical power to confirm this conclusively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71490","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:13:28Z","timestamp":1762758808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Omega\u20103 Long Chain Polyunsaturated Fatty Acid Supplementation for Prevention of Retinopathy of Prematurity in Pre\u2010Term Low Birth Weight Infants: A Pilot Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3908-2423","authenticated-orcid":false,"given":"Salma","family":"Afroz","sequence":"first","affiliation":[{"name":"Department of Pediatrics Bangladesh Shishu Hospital &amp; Institute Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mahbubul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Bangladesh Shishu Hospital &amp; Institute Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1056","volume-title":"Cloherty and Stark's Manual of Neonatal Care","author":"Leeman K. T.","year":"2017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42432-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2019.1585885"},{"key":"e_1_2_11_5_1","first-page":"559","volume-title":"Neonatology: Management, Procedures, On\u2010Call Problems, Diseases, and Drugs","author":"Gomella T. 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