{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:40:26Z","timestamp":1788525626395,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The emergence of antibiotic\u2010resistant strains of urinary tract infections (UTI) pathogens poses a significant challenge to the effective treatment of this condition. This study aimed to conduct a retrospective study to analyze the etiology and antibiotic resistance patterns of common urinary tract pathogens in the Ashanti Region of Ghana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study employed a standardized data collection form to extract information on age, sex, urine culture results, antibiotic susceptibility test results, and antibiotic treatment regimens from 2020 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary agent responsible for UTIs was\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      , identified in 47.8% of cases, followed by\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      at 15.8%,\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      at 9.2%, and\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      at 6.5%.\n                      <jats:italic>Candida<\/jats:italic>\n                      species were detected in 12% of cases, while coagulase\u2010negative Staphylococci constituted 3.8%.\n                      <jats:italic>Proteus<\/jats:italic>\n                      and\n                      <jats:italic>Providencia<\/jats:italic>\n                      species were observed in 1.1% and 0.5%, respectively.\n                      <jats:italic>E. coli<\/jats:italic>\n                      exhibited complete resistance (100%) to Nalidixic acid (NAL) and Ofloxacin (OFL), with varying degrees of resistance observed across other antibiotics. Among the 29 isolates of\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      , 90.0% showed resistance against Cefotaxime, 81.3% against Ciprofloxacin, and 80% against Trimethoprim\/Sulfamethoxazole. Sixty percent of\n                      <jats:italic>E. coli<\/jats:italic>\n                      isolates and 25% of\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      isolates demonstrated multi\u2010drug resistance and ESBL production.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The surge in multidrug\u2010resistant (MDR) gram\u2010negative isolates presents a significant healthcare hurdle for UTI patients. A noteworthy portion of prevalent pathogens, resistant to NAL and OFL, falls into the category of ESBL\u2010producing\n                      <jats:italic>Enterobacterales<\/jats:italic>\n                      and\n                      <jats:italic>Pseudomonas<\/jats:italic>\n                      spp. The limited availability of effective treatments for MDR gram\u2010negative isolates underscores the urgent need for innovative therapeutic alternatives.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71503","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T05:03:51Z","timestamp":1762923831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Regional Burden of Urinary Tract Infection, Its Aetiologies, and Antibiotic Resistance Patterns, 2020\u20132023: A Retrospective Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-6114","authenticated-orcid":false,"given":"Solomon","family":"Wireko","sequence":"first","affiliation":[{"name":"Deapartment of Laboratory Technology, Faculty of Health Sciences Kumasi Technical University Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gifty","family":"Ngmaakan","sequence":"additional","affiliation":[{"name":"Deapartment of Laboratory Technology, Faculty of Health Sciences Kumasi Technical University Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Dwomoh","sequence":"additional","affiliation":[{"name":"Deapartment of Laboratory Technology, Faculty of Health Sciences Kumasi Technical University Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Hansen","sequence":"additional","affiliation":[{"name":"Public Health and Reference Laboratory Ghana Health Service Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampson","family":"Nartey","sequence":"additional","affiliation":[{"name":"Public Health and Reference Laboratory Ghana Health Service Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2973-8952","authenticated-orcid":false,"given":"Ebenezer","family":"Senu","sequence":"additional","affiliation":[{"name":"Department of Medical Diagnostics Kwame Nkrumah University of Science and Technology Kumasi 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