{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:16:19Z","timestamp":1782774979627,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, and recent findings reveal that fertility and ovarian reserve are reduced even in moderate illness, showing that SLE has a direct impact on ovarian function. Therefore, this study aimed to evaluate ovarian reserve using Anti\u2010M\u00fcllerian hormone (AMH) and antral follicle count (AFC) in SLE patients compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2010control study was performed on 300 cases (150 SLE patients and 150 healthy controls). For evaluating ovarian reserve, AMH and AFC were evaluated. Furthermore, SLE activity was determined through the employment of the SLEDAI\u20102k questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Findings revealed that the mean serum levels of AMH were significantly lower in the SLE group as compared to healthy controls (1.34\u2009\u00b1\u20091.16 vs. 2.47\u2009\u00b1\u20091.48\u2009ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Moreover, left AFC (2.47\u2009\u00b1\u20091.57 vs. 5.3\u2009\u00b1\u20091.94,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), right AFC (2.77\u2009\u00b1\u20091.83 vs. 5.04\u2009\u00b1\u20092.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and mean AFC (2.62\u2009\u00b1\u20091.56 vs. 5.17\u2009\u00b1\u20091.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly lower in the SLE group compared to healthy controls. Moreover, the results of examining the relationship between controlled (SLEDAI\u20102K\u2009\u2264\u20094) and uncontrolled (SLEDAI\u20102K\u2009&gt;\u20094) patients were significant in terms of AMH serum levels, which were significantly lower in uncontrolled patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>According to the results of the present study, young women with SLE should check their ovarian reserve regularly, and both AMH and AFC should be evaluated periodically because ovarian reserve may be reduced faster in SLE cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71597","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:32:38Z","timestamp":1765783958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Beyond the Autoimmune Spectrum, Evaluating Ovarian Health in Systemic Lupus Erythematosus Patients: A Case\u2010Control Study"],"prefix":"10.1002","volume":"8","author":[{"given":"Shaghayegh Moradi","family":"Alamdarloo","sequence":"first","affiliation":[{"name":"Maternal\u2010Fetal Medicine Research Center, Department of Obstetrics and Gynecology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Naseri","sequence":"additional","affiliation":[{"name":"Gynecology Oncology Division, Department of Obstetrics and Gynecology, School of Medicine Shiraz University of Medical Science Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Habibagahi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameneh","family":"Keshavarzi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Fasa University of Medical Sciences Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefe","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Research Center, Department of Obstetrics and Gynecology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Haseli","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Musculoskeletal Imaging and Intervention UW Radiology\u2013Roosevelt Clinic, University of Washington Seattle Washington USA"},{"name":"OncoRad Research Core, Department of Radiology UW\/FHCC Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1675-7195","authenticated-orcid":false,"given":"Sepide","family":"Javankiani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"International Surgical Research Association (ISRA) Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6622"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8192-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21593"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.09.005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740902763099"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2017.09.011"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.183514"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMC.0000000000000145"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu163oa"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.224"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0478-3"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.8.737"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker105"},{"issue":"8","key":"e_1_2_12_16_1","first-page":"38","article-title":"Menstrual and Gonadal Function Alterations in Women With Systemic Lupus Erythematosus","volume":"63","author":"Mandal D.","year":"2015","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12249"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40738-015-0004-3"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000160"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.09.002"},{"issue":"10","key":"e_1_2_12_21_1","first-page":"347","article-title":"Cyclophosphamide\u2010Induced Gonadal Toxicity: A Treatment Dilemma in Patients With Lupus Nephritis","volume":"62","author":"Wetzels J. F.","year":"2004","journal-title":"Netherlands Journal of Medicine"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-5-199309010-00003"},{"key":"e_1_2_12_23_1","volume-title":"Systemic Lupus Erythematosus","author":"Justiz Vaillant A. A","year":"2021"},{"issue":"25","key":"e_1_2_12_24_1","first-page":"423","article-title":"The Diagnosis and Treatment of Systemic Lupus Erythematosus","volume":"112","author":"Kuhn A.","year":"2015","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"issue":"2","key":"e_1_2_12_26_1","first-page":"288","article-title":"Systemic Lupus Erythematosus Disease Activity Index 2000","volume":"29","author":"Gladman D. D.","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309346505"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310385163"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2014.09.006"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.12.093"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq034"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.043"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2014.908237"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317726378"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.922949"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1783-1"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315598246"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt062"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14763"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.186"},{"issue":"3","key":"e_1_2_12_42_1","first-page":"436","article-title":"Ovarian Function and Disease Activity in Patients With Systemic Lupus Erythematosus","volume":"26","author":"Shabanova S. S.","year":"2008","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"4","key":"e_1_2_12_43_1","first-page":"411","article-title":"An Update on Ovarian Aging and Ovarian Reserve Tests","volume":"9","author":"Amanvermez R.","year":"2016","journal-title":"International Journal of Fertility & Sterility"},{"issue":"1","key":"e_1_2_12_44_1","first-page":"38","article-title":"Evaluation of the Ovarian Reserve in Women With Systemic Lupus Erythematosus","volume":"15","author":"Morales\u2010Mart\u00ednez F. A.","year":"2021","journal-title":"Journal of Family & Reproductive Health"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah015"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01622-7"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.887064"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcreu.2021.05.006"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.4.224"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1063oa"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-020-01057-9"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq092"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.71597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:46:42Z","timestamp":1776167202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/hsr2.71597"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71597","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71597"}}