{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:47:01Z","timestamp":1776170821781,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Beh\u00e7et's disease (BD) is a systemic inflammatory vasculitis characterized by recurrent oral and genital ulcers; ocular and skin lesions; and vascular, gastrointestinal, and neurological involvement. The absence of specific laboratory markers for disease activity poses a significant challenge in managing BD. This study aimed to evaluate oxidative stress levels in the saliva of patients with active and inactive BD and explore their associations with disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 64 patients who were diagnosed with BD on the basis of the International Criteria for Beh\u00e7et's Disease (ICBD). Patients were divided into active and inactive groups on the basis of their clinical manifestations. Unstimulated whole saliva samples were collected, and oxidative stress markers, including total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI), were measured. Statistical analysis was performed to compare the oxidative stress levels between the two groups and assess their correlation with disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results revealed no significant difference in the levels of oxidative stress markers between patients with active and inactive BD. However, regression analysis indicated that disease activity was the strongest predictor of TAS, whereas smoking was the strongest predictor of TOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the absence of significant differences in salivary oxidative stress markers, this study highlights the potential of saliva as a noninvasive diagnostic tool for assessing oxidative stress in BD patients. Further research with larger sample sizes and additional biomarkers is recommended to better understand the role of oxidative stress in BD activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71610","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T06:53:22Z","timestamp":1764744802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Oxidative Stress Markers in Behcet's: A Comparative Study of Active and Inactive Diseases"],"prefix":"10.1002","volume":"8","author":[{"given":"Majid","family":"Alikhani","sequence":"first","affiliation":[{"name":"Rheumatology Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimia","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"School of Dentistry Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-4633","authenticated-orcid":false,"given":"Ghodratollah","family":"Panahi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedeh Tahereh","family":"Faezi","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"School of Dentistry Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Clinical Biochemistry School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Oral and Maxillofacial Medicine School of Dentistry Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-0747","authenticated-orcid":false,"given":"Mahdieh Sadat","family":"Moosavi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine School of Dentistry Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1093585"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2024.2410743"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1354969"},{"issue":"5","key":"e_1_2_14_5_1","first-page":"308","article-title":"Potential Biomarkers in Beh\u00e7et's Disease: Monocyte, Neutrophil, Platelet, and C\u2010Reactive Protein to Albumin Ratios","volume":"62","author":"Sahin M.","year":"2024","journal-title":"Rheumatology"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02416-4"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.043398"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12045"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0126-3"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5737"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6958293"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01863.x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2014.50.2.58"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2015.12.004"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05504.x"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.33425\/2639-8494.1027"},{"issue":"3","key":"e_1_2_14_17_1","first-page":"625","article-title":"Relationship Between Beh\u00e7et's Disease and Oxidant and Antioxidant Markers","volume":"9","author":"Akyurek F.","year":"2020","journal-title":"Medicine"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2018.0411"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.22631\/rr.2018.69997.1048"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.612735"},{"issue":"1","key":"e_1_2_14_22_1","article-title":"Salivary Diagnostics: A Brief Review","volume":"2014","author":"Malathi N.","year":"2014","journal-title":"ISRN Dentistry"},{"key":"e_1_2_14_23_1","first-page":"149","article-title":"Salivary and Serum Oxidant\/Antioxidant Level in Behcet's Disease Patients","volume":"4","author":"Mohammad N. H.","year":"2017","journal-title":"Journal of Oral Dental Research"},{"issue":"39","key":"e_1_2_14_24_1","first-page":"25","article-title":"Evalution of HSP70 Level in Patients \u2018Saliva With Active Oral Lesions of Behcet's Disease, in Comparation With Healthy Individuals","volume":"10","author":"Bonyadi N.","year":"2018","journal-title":"Laboratory & Diagnosis"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.34172\/ajdr.2019.24"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.71610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:50:38Z","timestamp":1776167438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/hsr2.71610"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71610","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71610"}}