{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:30:03Z","timestamp":1789846203726,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Chromosomal nondisjunction is the primary etiology of Down syndrome; however, genetic variations, environmental causes, and maternal etiologies also contribute to a great extent. The objective of this review is to evaluate these multifaceted factors during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive review of the literature of research and epidemiology was performed to examine the environmental factors, genetic factors, and clinical variables that influence Down syndrome. The research concludes with a discussion of new prenatal testing methods, the danger presented by increased maternal age, and how such issues impact the affected families.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The genetic polymorphisms were associated with a higher rate of chromosomal nondisjunction, particularly in the genes for folate metabolism, including MTHFR, RFC1, and MTHFD. These factors like education level of the mother, income, and access to prenatal care can raise or lower Down syndrome. People born with problems, like heart problems or problems with their intestines, tend to have problems with their bodies and minds also. The article also mentions how hard it is for parents to deal with the emotional weight of having a prenatal diagnosis and how common this condition is in different racial and cultural groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Down syndrome is still a complicated illness caused by genetics, the environment, and the mother. With enhanced prenatal screening to detect problems before birth, families still encounter moral and ethical dilemmas. We need to learn more through further research on genetic modifiers, how the environment affects them, and how they affect health in the long run. A deeper understanding of these concerns will make prenatal counseling more robust and more effective treatment procedures for individuals with Down syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71615","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T07:01:09Z","timestamp":1764918069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Multifactorial Causes of Down Syndrome During Pregnancy: A Narrative Review of Genetic, Environmental, and Maternal Influences"],"prefix":"10.1002","volume":"8","author":[{"given":"Md. Sohel","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology Khwaja Yunus Ali University Sirajganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst. Morium","family":"Parvin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Khwaja Yunus Ali University Sirajganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-8760","authenticated-orcid":false,"given":"Md. 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