{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:13:50Z","timestamp":1771244030011,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In Japan, about 6000 patients with hemophilia A (PwHA) are separately cared for at ~1000 clinics or hospitals. Interfacility collaboration (IFC) between hemophilia treatment centers and \u201csatellite\u201d medical facilities located closer to patients is necessary to eliminate care disparities. To facilitate IFC, the Japan Hemophilia Network Committee (JHNC) was approved in 2018 by the Japanese Society of Thrombosis and Hemostasis. However, it is unclear whether the JHNC is functioning effectively to provide comprehensive and specialized care to PwHA seen by doctors at non\u2010expert facilities. Therefore, we conducted a retrospective, longitudinal, observational study using the JMDC Claims Database to assess IFC for hemophilia A in Japan. Results are presented in adherence with the \u201cStrengthening the Reporting of Observational Studies in Epidemiology (STROBE)\u201d guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PwHA were classified into those who were usually treated at non\u2010expert\u00a0(\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200982) and expert (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200997) facilities. Using descriptive statistics, we assessed hemophilia\u2010specific care using records of joint examinations and blood coagulation tests in the JMDC database from April 2013 to March 2023. The JMDC claims database has several limitations, including the number of elderly patients and the total number of health insurance associations providing data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among patients who usually attended non\u2010expert facilities, the proportion who received hemophilia\u2010specific tests at expert facilities was persistently low during the observation period (6.9%\u201316.3% for joint examinations and 15.4%\u201332.6% for blood coagulation tests). The rate of visits to expert facilities among the non\u2010expert facilities group did not increase during the study period. The proportion of invasive procedures with bleeding risks performed at expert facilities was low (&lt;\u200920%), and some procedures requiring specialist consultation were performed at non\u2010expert facilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that IFC for the care of PwHA between non\u2010expert and expert hemophilia care medical facilities could be strengthened in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71643","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:44:56Z","timestamp":1768560296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interfacility Collaboration for Hemophilia Care in Japan: A Retrospective Database Study Using a Japanese Healthcare Claims Database"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-0854","authenticated-orcid":false,"given":"Ei","family":"Kinai","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4011-3918","authenticated-orcid":false,"given":"Masako","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Japan Medical Office, Takeda Pharmaceutical Company Limited Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shirahata","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health, Japan Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01123-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-1208"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_12_5_1","unstructured":"Japan Foundation for AIDS Prevention \u201cNationwide Survey on Coagulation Disorders\u201d [in Japanese] (2023) https:\/\/api\u2010net.jfap.or.jp\/image\/data\/blood\/r05_research\/r05_research.pdf."},{"key":"e_1_2_12_6_1","first-page":"287","article-title":"Collaborative Care of Patients With Hemophilia in Japan","volume":"56","author":"Shirahata A.","year":"2019","journal-title":"Japanese Journal of Pediatric Hematology\/Oncology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2491\/jjsth.24.619"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620718799997"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011847"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2018.24.7.632"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2001.00521.x"},{"issue":"3","key":"e_1_2_12_13_1","first-page":"s515","article-title":"The European Haemophilia Network (EUHANET)","volume":"12","author":"Makris M.","year":"2014","journal-title":"Blood Transfusion"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12810"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_12_16_1","unstructured":"JHNC of the Japanese Society of Thrombosis and Hemostasis \u201cListing of Regional Block Core Hospitals (as of 4 July 2021)\u201d [in Japanese] (2021) https:\/\/www.jsth.org\/wordpress\/wp\u2010content\/uploads\/2021\/09\/\u30d6\u30ed\u30c3\u30af\u62e0\u70b9\u75c5\u9662\u30ea\u30b9\u30c8.pdf."},{"key":"e_1_2_12_17_1","unstructured":"JHNC of the Japanese Society of Thrombosis and Hemostasis \u201cListing of Local Core Hospitals (as of 1 January 2023)\u201d [in Japanese] (2023) https:\/\/www.jsth.org\/wordpress\/wp\u2010content\/uploads\/2021\/09\/\u5730\u57df\u4e2d\u6838\u75c5\u9662\u30ea\u30b9\u30c820230101.pdf."},{"key":"e_1_2_12_18_1","unstructured":"World Federation of Hemophilia Report on the Annual Global Survey 2021(World Federation of Hemophilia 2022) https:\/\/www1.wfh.org\/publications\/files\/pdf\u20102324.pdf."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13456"},{"key":"e_1_2_12_20_1","first-page":"437","article-title":"Mortality Among Males With Hemophilia: Relations With Source of Medical Care","volume":"96","author":"Soucie J. 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