{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:13:55Z","timestamp":1771244035686,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Thalassemia is a hereditary hematological condition which interferes with the production of hemoglobin (Hb). Patients with thalassemia require regular blood transfusion, which makes them highly susceptible to pathogens, and especially viral pathogens. Hepatitis C virus (HCV) is also a big threat in that it is hepatotropic in nature and has the potential of causing hepatic injury. Host genetic factors, such as single nucleotide polymorphisms (SNPs) in the IFN \u03bb3 (IL28B) gene, influence the ability to clear the virus and respond to therapy. In this research, we aimed to determine the frequency of the rs8099917 and rs12979860 polymorphisms of the IL28B gene in HCV\u2010infected thalassemia patients from southern Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010five people with \u03b2\u2010thalassemia were recruited, including 25 people who are HCV positive and 40 people who are HCV negative. The genotyping of the locus at the rs8099917 and rs12979860 sites was done using the tetra\u2010primer amplification refractory mutation system\u2010polymerase chain reaction (T\u2010ARMS\u2010PCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On analyzing the locus at rs8099917, we noted that the TT genotype was common among patients who had HCV, with the proportion of 72% versus 12.5% among HCV\u2010negative individuals. The GG genotype was also rare in the HCV\u2010positive group and not present in the HCV\u2010negative group. On the other hand, TG genotype were found in 20% of the HCV\u2010positive patients with 87.5% of the HCV\u2010negative subjects, presenting a very significant difference (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001). On the other hand, the distribution of the rs12979860 genotype was not significantly different in the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that the rs8099917 SNP of the IL28B gene may serve as a useful baseline predictor of antiviral responses in thalassemia patients infected with HCV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71648","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T05:41:42Z","timestamp":1766900502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of IL28B Polymorphisms With Hepatitis C Susceptibility in Southern Iran's \u03b2\u2010Thalassemia Population: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Fatemeh","family":"Askari","sequence":"first","affiliation":[{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-8939","authenticated-orcid":false,"given":"Masoud","family":"Kargar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-5904","authenticated-orcid":false,"given":"Zeinab","family":"Deris Zayeri","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-0325","authenticated-orcid":false,"given":"Mohammad Ali","family":"Jalalifar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijan","family":"Keikhaei","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-3238","authenticated-orcid":false,"given":"Gholam Abbas","family":"Kaydani","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, School of Allied Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Thalassemia and Hemoglobinopathy Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.101028"},{"issue":"2","key":"e_1_2_14_3_1","first-page":"1","article-title":"Beta Thalassemia Major: Overview of Molecular Etiology, Pathophysiology, Current and Novel Therapeutic Approaches","volume":"10","author":"El Kababi S.","year":"2019","journal-title":"International Blood Research & Reviews"},{"key":"e_1_2_14_4_1","unstructured":"\u201cThalassaemia Patients Have Renewed Hope Through Support Provided by the Emergency Health and Nutrition Project \u201d World Health Organization 2019."},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/635183"},{"issue":"1","key":"e_1_2_14_6_1","first-page":"15","article-title":"Prevalence of Depression Among Iranian Patients With Beta\u2010Thalassemia Major: A Systematic Review and 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