{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:13:58Z","timestamp":1771244038900,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>While previous publications have briefly pointed out a few alternative therapeutic interventions for the treatment of histoplasmosis and tuberculosis coinfections in patients with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), there are no reviews evaluating the efficacy, effectiveness, and safety of different regimens. Thus, this protocol outlines the approach for systematically reviewing and synthesizing the existing literature regarding the efficacy, effectiveness, and safety of different regimens for histoplasmosis and tuberculosis coinfection treatment in patients with HIV\/AIDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search will be conducted using PubMed, Embase, and Latin American and Caribbean Health Sciences Literature (LILACS) databases. Studies will be selected in two distinct stages, and data from selected studies will be extracted. Risk of bias will be assessed using the RoB 2, ROBINS\u2010I, NOS, and JBI tools, depending on the type of study. Finally, the strength of the body of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this review may positively impact public health, stimulating the implementation of evidence\u2010based practices and guiding the adoption of specific treatment protocols for patients with HIV\/AIDS coinfected with histoplasmosis and tuberculosis in endemic regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71720","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T16:41:14Z","timestamp":1767717674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy, Effectiveness, and Safety of Treatment Regimens for Histoplasmosis and Tuberculosis Coinfection in Patients With Human Immunodeficiency Virus\/Acquired Immunodeficiency Syndrome: A Systematic Review With Meta\u2010Analysis Protocol"],"prefix":"10.1002","volume":"9","author":[{"given":"Beatriz Bernava","family":"Sarinho","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inajara","family":"Rotta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Federal University of Paran\u00e1 Curitiba PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e1cio de Mendon\u00e7a","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Administration, Faculty of Pharmacy Fluminense Federal University Niteroi RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Br\u00edgida Dias","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Capixaba Institute of Education Research and Innovation in Health Vit\u00f3ria ES Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Melo","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1433-4768","authenticated-orcid":false,"given":"Mar\u00edlia Berlofa","family":"Visacri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361211008675"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09257-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822008000300005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0292"},{"key":"e_1_2_11_6_1","unstructured":"\u201cConsolidated Guidelines on HIV Prevention Testing Treatment Service Delivery and Monitoring: Recommendations for a Public Health Approach \u201d World Health Organization (WHO) accessed July 17 2025 https:\/\/www.who.int\/publications\/i\/item\/9789240031593."},{"key":"e_1_2_11_7_1","unstructured":"\u201cWHO Consolidated Guidelines on Tuberculosis. Module 4: Treatment and Care \u201d World Health Organization (WHO) accessed July 17 2025 https:\/\/www.who.int\/publications\/i\/item\/9789240107243."},{"key":"e_1_2_11_8_1","unstructured":"\u201cGuidelines for Diagnosing and Managing Disseminated Histoplasmosis Among People Living With HIV [Procedures manuals guidelines] \u201d PAHO published 2020 https:\/\/iris.paho.org\/handle\/10665.2\/52304."},{"key":"e_1_2_11_9_1","unstructured":"\u201cGuidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV \u201d Department of Health and Human Services (HHS) accessed February 23 2025 https:\/\/clinicalinfo.hiv.gov\/sites\/default\/files\/guidelines\/documents\/adult-adolescent-arv\/guidelines-adult-adolescent-arv.pdf."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05413-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-021-11170-9"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_15_1","unstructured":"G. A.Wells B.Shea D.O'Connell et al. \u201cThe Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta\u2010Analyses accessed February 23 2025 http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_11_16_1","unstructured":"Joanna Briggs Institute (JBI) \u201cJBI\u202fCritical Appraisal Tools \u201d JBI Global accessed December 12 2025 https:\/\/jbi.global\/critical-appraisal-tools."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_11_18_1","unstructured":"J. P. T.Higgins J.Thomas J.Chandler et al. eds. \u201cCochrane Handbook for Systematic Reviews of Interventions version 6.5 \u201d accessed February 23 2025 www.training.cochrane.org\/handbook."}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.71720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:27:42Z","timestamp":1771241262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/hsr2.71720"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71720","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71720"}}