{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:13:46Z","timestamp":1771244026191,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Although the global plan aimed to eliminate mother\u2010to\u2010child transmission of HIV by 2015, an estimated 130,000 children were newly infected, and 84,000 children died from HIV related causes in 2022. In Ethiopia, 3200 children became newly infected and 1,900 children died from HIV related causes in 2022. A new target has now been set for 2030. Vertical transmission remains the predominant route of pediatric HIV infection. This study aimed to assess HIV vertical transmission and its predictors among HIV\u2010exposed infants in Northwest Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study was conducted among 480 mother\u2013infant pairs enrolled in the PMTCT program. Data were analyzed using R version 4.3.2. To account for missing values, multiple imputations were performed prior to bivariate and multivariable logistic regression analyses. Associations with a\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.05 were considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The rate of vertical transmission of HIV was 3.6%. Mothers residing outside the catchment area (AOR\u2009=\u20094.74; 95% CI: 1.17\u201320.63) and those not receiving antiretroviral therapy (AOR\u2009=\u20096.82; 95% CI: 1.33\u201338.73) had significantly higher odds of vertical HIV transmission. Conversely, maternal HIV diagnosis prior to pregnancy (AOR\u2009=\u20090.08; 95% CI: 0.009\u20130.84), receiving Nevirapine prophylaxis (AOR\u2009=\u20090.14; 95% CI: 0.03\u20130.65), and delivery at a health facility (AOR\u2009=\u20090.08; 95% CI: 0.01\u20130.66) were significantly protective against mother\u2010to\u2010child transmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The rate of vertical HIV transmission was found to be high. Therefore, we recommend further PMTCT service expansion; focus on maternal HIV diagnosis in the preconception period; improve provision of infant Nevirapine prophylaxis and maternal ART help to minimize HIV vertical transmission. Reduce home delivery also helps to decrease HIV vertical transmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71766","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:30:52Z","timestamp":1768969852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of HIV Vertical Transmission in Exposed Infants in Northwest, Ethiopia: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-9555","authenticated-orcid":false,"given":"Amare Genetu","family":"Ejigu","sequence":"first","affiliation":[{"name":"Department of Midwifery, College of Medicine and Health Sciences Injibara University Injibara Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilahun Degu","family":"Tsega","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public 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Injibara University Injibara Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abebaw Molla","family":"Kebede","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Cheeloo College of Medicine Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-648X","authenticated-orcid":false,"given":"Gashaw Melkie","family":"Bayeh","sequence":"additional","affiliation":[{"name":"Department of environmental health, college of medicine and health science Injibara University Injibara Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1000-9220","authenticated-orcid":false,"given":"Chalachew","family":"Yenew","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Public Health, College of Health Sciences Debre Tabor University Debre Tabor 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