{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:27:55Z","timestamp":1783013275900,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Butylphthalide (NBP) is a neuroprotective agent that ameliorates cerebral ischemia\u2010hypoxia and reperfusion injury. However, evidence regarding whether NBP can improve neurological prognosis in patients with cardiac arrest (CA) remains limited. The present study aims to evaluate the efficacy and safety of butylphthalide treatment in improving neurological function in patients with cardiac arrest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This research constituted a single\u2010center, randomized, double\u2010blind, placebo\u2010controlled trial. Those meeting the inclusion criteria were randomly allocated to either the NBP group or the Placebo group at a 1:1 ratio. The primary outcome was the proportion of patients with a Cerebral Performance Category (CPC) score of 1 or 2 in each group at 90 days after randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 70 patients were included in the final analysis, of whom 34 were in the placebo group and 36 in the NBP group. No statistically significant differences were observed in baseline characteristics between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Similarly, no statistically significant differences were noted between the two groups in the proportion of patients with CPC scores of 1 or 2 at 90 days, in\u2010hospital mortality, or Glasgow Coma Scale (GCS) scores at discharge (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, compared with the placebo group, the NBP group exhibited significantly lower levels of brain injury biomarkers, including neuron\u2010specific enolase (NSE), glial fibrillary acidic protein (GFAP), and ubiquitin C\u2010terminal hydrolase L1 (UCHL1), after 14 days of treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, no statistically significant differences were found between the two groups in terms of safety outcomes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although butylphthalide treatment significantly reduced levels of brain injury biomarkers in patients with cardiac arrest, it did not significantly improve their 90\u2010day neurological prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71794","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T04:47:24Z","timestamp":1769489244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Butylphthalide for Neurological Recovery After Cardiac Arrest: A Pilot Randomized Controlled Trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Xingsheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"An","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-4099","authenticated-orcid":false,"given":"Ziren","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.02.044"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.121.008856"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3043-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003966"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X19500265"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520936177"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045559"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0608"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18776833"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.1871"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310519"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3174"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1933"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450240073043"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","unstructured":"Brain Resuscitation Clinical Trial II Study Group. 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