{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:36Z","timestamp":1787250336473,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Although combination antiretroviral therapy has decreased morbidity and mortality in people living with HIV (PLWH), the prevalence of other sexually transmitted and blood\u2010borne infections (STBBIs) is rising within this population. We used Latent Class Analysis to examine the diverse lab testing and diagnostic patterns of PLWH in British Columbia (BC), Canada to identify subpopulations of PLWH for targeted STBBI interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our study population included all known PLWH with at least one STBBI lab test or diagnosis in BC between December 2003 and March 2020. Lab data were sourced from the BC Center for Excellence in HIV\/AIDS Drug Treatment Program. We used Latent Class Analysis to group study participants based on lab testing and diagnostic data for gonorrhea, chlamydia, syphilis, hepatitis C virus (HCV), and hepatitis B virus (HBV). To compare the demographic compositions of each class, we used two\u2010tailed logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We assigned 9,328 study participants to one of four classes. The 2029 participants assigned to Class 1 (21.7% of our study population) tested for syphilis and HCV, with few diagnoses. Those in Class 2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092868; 30.7%) tested for HBV, HCV, and syphilis, with some being diagnosed with HCV and HBV. Class 3, the largest group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093154; 33.8%), tested for all STBBIs but had few diagnoses. Finally, Class 4 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091279; 13.7%) had higher testing and diagnoses for all STBBIs. Demographic composition varied significantly between classes; for example, participants in Class 4 had 7.42 times greater odds of being men who have sex with men compared to those in Class 1 (95% CI: 6.20\u20138.89).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified key subpopulations of PLWH based on STBBI testing and diagnosis. By taking a holistic approach and studying overall patterns in STBBI lab data, this work will help inform public health efforts and guide interventions targeting STBBIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.71801","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:22:40Z","timestamp":1772965360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Subgroups of People Living With HIV in British Columbia, Canada Based on Sexually Transmitted and Blood\u2010Borne Infection Testing and Diagnostic Laboratory Data: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4893-4409","authenticated-orcid":false,"given":"Amanda M.","family":"Yonkman","sequence":"first","affiliation":[{"name":"BC Center for Excellence in HIV\/AIDS Vancouver Canada"},{"name":"Faculty of Health Sciences Simon Fraser University Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Emerson","sequence":"additional","affiliation":[{"name":"BC Center for Excellence in HIV\/AIDS Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-8089","authenticated-orcid":false,"given":"Paul","family":"Sereda","sequence":"additional","affiliation":[{"name":"BC Center for Excellence in HIV\/AIDS Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nic","family":"Bacani","sequence":"additional","affiliation":[{"name":"BC Center for Excellence in HIV\/AIDS Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junine","family":"Toy","sequence":"additional","affiliation":[{"name":"BC Center for Excellence in HIV\/AIDS Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane D.","family":"Lima","sequence":"additional","affiliation":[{"name":"BC Center for Excellence in HIV\/AIDS Vancouver Canada"},{"name":"Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio S.G.","family":"Montaner","sequence":"additional","affiliation":[{"name":"BC Center for Excellence in HIV\/AIDS Vancouver Canada"},{"name":"Faculty of Medicine University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(24)00094-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2254-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa347"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idm.2020.10.008"},{"issue":"12","key":"e_1_2_10_6_1","first-page":"527","article-title":"Sexually Transmitted Infections and Increased Risk of Co\u2010Infection With Human Immunodeficiency Virus","volume":"104","author":"Nusbaum M. 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